Evidence map›Paper›PMID 29404444›Full record

ArticleHepatology communications2017

Hairy and enhancer of split 6 prevents hepatic lipid accumulation through inhibition of

Jung Eun Park, Mikang Lee, Seong-Chul Kim, Yanqiao Zhang, James P Hardwick, Yoon Kwang Lee

Open access · goldAbstract read
In one paragraph

Article in Hepatology communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jung Eun ParkDepartment of Integrative Medical Sciences Northeast Ohio Medical University Rootstown Ohio.
Mikang LeeDepartment of Integrative Medical Sciences Northeast Ohio Medical University Rootstown Ohio.
Seong-Chul KimDepartment of Integrative Medical Sciences Northeast Ohio Medical University Rootstown Ohio.
Yanqiao ZhangDepartment of Integrative Medical Sciences Northeast Ohio Medical University Rootstown Ohio.
James P HardwickDepartment of Integrative Medical Sciences Northeast Ohio Medical University Rootstown Ohio.
Yoon Kwang LeeDepartment of Integrative Medical Sciences Northeast Ohio Medical University Rootstown Ohio.
Northeast Ohio Medical University · US

Funding

Mechanisms Underlying the Pathogenesis of Non-alcoholic Fatty Liver DiseaseR01DK102619 · NIDDK · UNIVERSITY OF ARIZONA · PI Yanqiao Zhang · 2015 to 2026
$4.0M
Regulation of Lipid and Lipoprotein Metabolism by Nuclear ReceptorsR01HL103227 · NHLBI · NORTHEAST OHIO MEDICAL UNIVERSITY · PI YIN, LIYA, ZHANG, YANQIAO · 2011 to 2019
$3.1M
Hepatic Lipid Mobilization by Nuclear Hormone ReceptorsR01DK093774 · NIDDK · NORTHEAST OHIO MEDICAL UNIVERSITY · PI LEE, YOON-KWANG · 2013 to 2017
$1.5M
NHLBI NIH HHS R01 HL103227NIDDK NIH HHS R01 DK093774NIDDK NIH HHS R01 DK102619
6 · The paper itself

Abstract

Peroxisome proliferator-activated receptor gamma (PPARγ) is a master regulator for white adipocyte differentiation and lipid storage. The increased level of hepatic PPARγ2 isoform reprograms liver for lipid storage and causes abnormal fat accumulation in certain pathophysiologic conditions. The current study aimed to investigate a role of transcriptional repressor hairy and enhancer of split 6 (HES6) in the regulation of

Identifiers

PMID29404444
PMCPMC5721401
OpenAlexW2767563252

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.