Evidence map›Paper›PMID 29404441›Full record

ArticleHepatology communications2017

The role of human cytochrome P450 2E1 in liver inflammation and fibrosis.

Jun Xu, Hsiao-Yen Ma, Shuang Liang, Mengxi Sun, Gabriel Karin, Yukinori Koyama, Ronglin Hu, Oswald Quehenberger, Nicholas O Davidson, Edward A Dennis and 2 more

Open access · goldAbstract read
In one paragraph

Article in Hepatology communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 70 citations in OpenAlex.

  1. Review
  2. Precision pathophysiology in steatotic liver disease.Clinical and molecular hepatology · 2026
    Review
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  4. Review
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  8. Review
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  11. Review
  12. Review
  13. Hepatoprotective effects ofFood science & nutrition · 2024
    Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Human Hepatic Stellate Cells: Isolation and Characterization.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Jun XuDepartment of Medicine University of California San Diego La Jolla CA.
Hsiao-Yen MaDepartment of Medicine University of California San Diego La Jolla CA.
Shuang LiangDepartment of Medicine University of California San Diego La Jolla CA.
Mengxi SunDepartment of Medicine University of California San Diego La Jolla CA.
Gabriel KarinDepartment of Medicine University of California San Diego La Jolla CA.
Yukinori KoyamaDepartment of Medicine University of California San Diego La Jolla CA.
Ronglin HuDepartment of Medicine University of California San Diego La Jolla CA.
Oswald QuehenbergerDepartment of Medicine University of California San Diego La Jolla CA.
Nicholas O DavidsonDepartment of Medicine Washington University School of Medicine St. Louis MO.
Edward A DennisDepartment of Pharmacology University of California San Diego La Jolla CA.
Tatiana KisselevaDepartment of Surgery University of California San Diego La Jolla CA.
David A BrennerDepartment of Medicine University of California San Diego La Jolla CA.
University of California, San Diego · USWashington University in St. Louis · US

Funding

Yeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8M
The Southernearch Center for ALPD and CirrhosisP50AA011999 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ANNA S. GUKOVSKAYA · 1999 to 2026
$45.8M
Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8M
HEPATIC SYNTHESIS AND SECRETION OF APOLIPOPROTEIN (A)R01DK056260 · NIDDK · WASHINGTON UNIVERSITY · PI DAVIDSON, NICHOLAS O. · 1999 to 2017
$5.9M
ENTEROHEPATIC LIPID FLUX AND APOPROTEIN BIOSYNTHESIS.R37HL038180 · NHLBI · WASHINGTON UNIVERSITY · PI DAVIDSON, NICHOLAS O. · 2000 to 2009
$5.1M
Inactivation of Hepatic Stellate Cells During Reversal of Liver FibrosisR01DK099205 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRENNER, DAVID A., KISSELEVA, TATIANA · 2014 to 2025
$4.8M
ENTEROHEPATIC LIPID FLUX AND APOPROTEIN BIOSYNTHESISR01HL038180 · NHLBI · WASHINGTON UNIVERSITY · PI DAVIDSON, NICHOLAS O. · 1986 to 2018
$3.8M
LIPIDOMICS BASED DIAGNOSTICS FOR NONALCOHOLIC STEATOHEPATITISR01DK105961 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI DENNIS, EDWARD A, SANYAL, ARUN J · 2015 to 2018
$2.8M
Genetic Regulation of Adiposity and Associated CVD RisksR01DK064391 · NIDDK · WRIGHT STATE UNIVERSITY · PI TOWNE, BRADFORD · 2003 to 2007
$2.7M
Microbiome as Therapeutic Target in Alcoholic HepatitisU01AA021856 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRENNER, DAVID A., SCHNABL, BERND G. · 2013 to 2017
$2.1M
Fibrocytes regulate liver fibrosisR01DK111866 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KISSELEVA, TATIANA · 2017 to 2020
$1.4M
Bile acid metabolomics and metagenomics in short bowel syndromeR01DK112378 · NIDDK · WASHINGTON UNIVERSITY · PI DAVIDSON, NICHOLAS O., RUBIN, DEBORAH C. · 2016 to 2018
$1.1M
NHLBI NIH HHS R01 HL038180NHLBI NIH HHS R37 HL038180NIAAA NIH HHS P50 AA011999NIAAA NIH HHS U01 AA021856NIDDK NIH HHS P30 DK052574NIDDK NIH HHS R01 DK056260NIDDK NIH HHS R01 DK064391NIDDK NIH HHS R01 DK099205NIDDK NIH HHS R01 DK105961NIDDK NIH HHS R01 DK111866NIDDK NIH HHS R01 DK112378NIEHS NIH HHS P42 ES010337
6 · The paper itself

Abstract

Cytochrome P450 2E1 (

Identifiers

PMID29404441
PMCPMC5721400
OpenAlexW2767062996

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.