Evidence map›Paper›PMID 29404420›Full record

ArticlemSphere

Limited Evidence for Infection of Urban and Peri-urban Nonhuman Primates with Zika and Chikungunya Viruses in Brazil.

Andres Moreira-Soto, Ianei de Oliveira Carneiro, Carlo Fischer, Marie Feldmann, Beate M Kümmerer, Nama Santos Silva, Uilton Góes Santos, Breno Frederico de Carvalho Dominguez Souza, Fernanda de Azevedo Liborio, Mônica Mafra Valença-Montenegro and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 3 countries.

Andres Moreira-Soto *Institute of Virology, University of Bonn Medical Centre, Bonn, Germany.
Ianei de Oliveira Carneiro *Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Virology, Berlin, Germany.
Carlo FischerCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Virology, Berlin, Germany.
Marie FeldmannInstitute of Virology, University of Bonn Medical Centre, Bonn, Germany.
Beate M KümmererInstitute of Virology, University of Bonn Medical Centre, Bonn, Germany.
Nama Santos SilvaFederal University of Bahia, Salvador, Brazil.
Uilton Góes SantosFederal University of Reconcavo of Bahia, Cruz das Almas, Brazil.
Breno Frederico de Carvalho Dominguez SouzaFederal University of Bahia, Salvador, Brazil.
Fernanda de Azevedo LiborioWild Animal Triage Center, Salvador, Brazil.
Mônica Mafra Valença-MontenegroNational Center for Research and Conservation of Brazilian Primates, Joao Pessoa, Brazil.
Plautino de Oliveira LaroqueNational Center for Research and Conservation of Brazilian Primates, Joao Pessoa, Brazil.
Fernanda Rosa da FontouraBrasilia Zoo Foundation, Brasilia, Brazil.
Alberto Vinicius Dantas OliveiraZoobotanic Park Getúlio Vargas, Salvador, Bahia, Brazil.
Christian DrostenCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Virology, Berlin, Germany.
Xavier de LamballerieUMR Emergence des Pathologies Virales (EPV), Aix-Marseille University, IRD 190, Inserm 1207, EHESP, IHU Méditerranée-Infection, Marseille, France.
Carlos Roberto FrankeFederal University of Bahia, Salvador, Brazil.
Jan Felix DrexlerCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Virology, Berlin, Germany.
Freie Universität Berlin · DEUniversidade Federal da Bahia · BRUniversity of Bonn · DECharité - Universitätsmedizin Berlin · DEÉcole des Hautes Études en Santé Publique · FRFundação Getulio Vargas · BRUniversidade Federal do Recôncavo da Bahia · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chikungunya virus (CHIKV) and Zika virus (ZIKV) emerged in the Americas in 2013. Limited antigenic variability of CHIKV and ZIKV may restrict urban transmission cycles due to population protective immunity. In Africa, sylvatic transmission cycles involving nonhuman primates (NHP) are known for CHIKV and ZIKV, causing cyclic reemergence in humans. To evaluate whether sylvatic cycles can be expected in Latin America, we tested 207 NHP collected between 2012 and 2017 in urban and peri-urban settings in Brazil for infection with ZIKV and CHIKV. No animal tested positive for viral RNA in genus-specific and species-specific reverse transcription-PCR (RT-PCR) assays. In contrast, six animals (2.9%) from the families Atelidae, Callitrichidae, and Cebidae showed ZIKV-specific antibodies and 11 (5.3%) showed CHIKV-specific antibodies in plaque reduction neutralization tests (PRNT). Reactivity was monotypic against either ZIKV or CHIKV in all cases, opposing unspecific virucidal activity of sera. PRNT endpoint titers were low at 1:40 in all NHP, and positive specimens did not correspond to the likely dispersal route and time of introduction of both arboviruses. All antibody-positive samples were therefore tested against the NHP-associated yellow fever virus (YFV) and Mayaro virus (MAYV) and against the human-associated dengue virus (DENV) by PRNT. Two ZIKV-positive samples were simultaneously DENV positive and two CHIKV-positive samples were simultaneously MAYV positive, at titers of 1:40 to 1:160. This suggested cross-reactive antibodies against heterologous alphaviruses and flaviviruses in 24% of ZIKV-positive/CHIKV-positive sera. In sum, low seroprevalence, invariably low antibody titers, and the distribution of positive specimens call into question the capability of ZIKV and CHIKV to infect New World NHP and establish sylvatic transmission cycles.

Indexed as

alphaviruschikungunya virusflavivirusnonhuman primatesZika virus

Identifiers

PMID29404420
PMCPMC5793042
OpenAlexW2792516064

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.