ArticleAnnals of translational medicine2018
Stress-induced thrombus: prevalence of thromboembolic events and the role of anticoagulation in Takotsubo cardiomyopathy.
Article in Annals of translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic factors of Takotsubo cardiomyopathy: a systematic review.ESC heart failure · 2021Pooled it
- Takotsubo Cardiomyopathy: An Exploration of the Intersection Between Stress, Coronary Dysfunction, and Cardiac Outcomes.Reviews in cardiovascular medicine · 2025Review
- A cycle of complications: a case report on trastuzumab-induced takotsubo cardiomyopathy causing left ventricular thrombosis complicated by thromboembolic stroke.European heart journal. Case reports · 2025Article
- Takotsubo pathophysiology and complications: what we know and what we do not know.Heart failure reviews · 2024Review
- Inflammatory Forms of Cardiomyocyte Cell Death in the Rat Model of Isoprenaline-Induced Takotsubo Syndrome.Biomedicines · 2023Article
- Broken Heart Syndrome: Evolving Molecular Mechanisms and Principles of Management.Journal of clinical medicine · 2022Review
- Takotsubo cardiomyopathy with LVOT obstruction in a case of STEMI: a rare cause of peri-PCI hypotension.BMJ case reports · 2021Article
- Cardiovascular Imaging in Stress Cardiomyopathy (Takotsubo Syndrome).Frontiers in cardiovascular medicine · 2021Review
- A biventricular takotsubo cardiomyopathy complication: large thrombus formation to stroke in 150 min.BMJ case reports · 2020Article
- Understanding Atrial Cardiopathy: an Under-Recognized Contributor to Cardioembolic Stroke.Current treatment options in neurology · 2019Review
- Stress Cardiomyopathy Diagnosis and Treatment: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2018Review
- Spontaneous splenic rupture secondary to dabigatran: the last in a series of unfortunate events.Clinical medicine (London, England) · 2018Article
- Acute arterial occlusion due to left ventricular thrombus of Takotsubo cardiomyopathy in a young adult: a case report.JA clinical reports · 2018Article
- A Tale of 2 Morbid Complications in a Patient With Takotsubo Cardiomyopathy.Journal of investigative medicine high impact case reportsArticle
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTakotsubo cardiomyopathy (TCM), also known as stress-induced cardiomyopathy has a favorable prognosis with expected recovery in weeks. Left ventricular (LV) thrombus is a known complication of TCM, which can lead to embolization and potentially a stroke. The prevalence of LV thrombus and the role of anticoagulation have yet to be fully defined in this condition.
methodsWe performed a search of published literature through PubMed and Scopus, which identified 282 patients with TCM in whom the incidence of LV thrombus and/or thromboembolic event was reported. In order to contrast this to the current anticoagulation strategy of atrial fibrillation, the occurrence of LV thrombus was compared to the adjusted stroke rate using the CHADS2 score.
resultsOf the 282 patients identified through a literature search, 26 (9.2%) were noted to have a thromboembolic event in the setting of TCM. The incidence of thromboembolic event ranged from 5.3% to as high as 14.3%. When compared to the CH2sDS2-VASc score, the average incidence of LV thrombus in our study equated to a score between 4 and 5.
conclusionsWhile the occurrence of LV thrombus in TCM is variable among studies, the average incidence remains relatively high. Thus, making LV thrombus a significant complication of stress-induced cardiomyopathy. Prophylactic anticoagulation until recovery may have a role in reducing the rate of LV thrombus. Further studies will be needed to determine the rate of embolization and utility of anticoagulation in TCM.
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