Evidence map›Paper›PMID 29404349›Full record

ArticleAnnals of translational medicine2018

Impact of family history of coronary artery disease on in-hospital clinical outcomes in ST-segment myocardial infarction.

Manyoo A Agarwal, Lohit Garg, Carl J Lavie, Guy L Reed, Rami N Khouzam

Open access · hybridAbstract read
In one paragraph

Article in Annals of translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Manyoo A AgarwalDepartment of Internal Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Lohit GargDivision of Cardiovascular Medicine, Department of Internal Medicine, Lehigh Valley Medical Center, Allentown, PA, USA.
Carl J LavieDivision of Cardiovascular Medicine, Department of Internal Medicine, John Ochsner Heart and Vascular Institute, New Orleans, LA, USA.
Guy L ReedDepartment of Internal Medicine, Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, TN, USA.
Rami N KhouzamDepartment of Internal Medicine, Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, TN, USA.
University of Tennessee Health Science Center · USSanta Clara Valley Medical Center · US

Funding

Alpha-2-antiplasmin and Ischemic StrokeR01NS089707 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI REED, GUY L · 2015 to 2019
$1.9M
Novel Methods for Dissolving Blood ClotsR42HL092750 · NHLBI · TRANSLATIONAL SCIENCES, INC. · PI REED, GUY L · 2012 to 2013
$1.5M
HLS Potent, novel inhibitor of fibrinolytic hemorrhageR43HL137514 · NHLBI · TRANSLATIONAL SCIENCES, INC. · PI REED, GUY L, ZHAO, TIEQIANG · 2017 to 2017
$351k
NHLBI NIH HHS R42 HL092750NHLBI NIH HHS R43 HL137514NINDS NIH HHS R01 NS089707
6 · The paper itself

Abstract

backgroundPatients with a family history of coronary artery disease (FHxCAD) are at increased risk for development of myocardial infarction (MI). However, the data on the influence of FHxCAD on in-hospital clinical outcomes post ST-segment myocardial infarction (STEMI) is limited. Hence, we evaluated the impact of FHxCAD on in-hospital clinical outcomes post STEMI in an unselected nationwide cohort.

methodsNationwide Inpatient Sample (NIS) database [2003-2011] was used to compare differences in all-cause in-hospital mortality and adverse clinical events (cardiogenic shock, acute cerebrovascular events and use of intra-aortic balloon pump) between patients with and without FHxCAD.

resultsA total of 2,123,492 STEMI admissions were identified, of which 7.4% (n=158,079) patients were with FHxCAD and 92.6% (n=1,965,413) were without FHxCAD. The FHxCAD group had lower in-hospital mortality [1.4%

conclusionsThis large sample size study demonstrates that STEMI patients with FHxCAD had lower in-hospital mortality and adverse clinical events in comparison to patients with no-FHxCAD. Further research is warranted to determine whether the superior outcomes in FHxCAD patients with STEMI are related to differences in strategies related to diet, exercise, use of medications or coronary interventions.

Indexed as

Coronary artery diseasefamily historymortalitymyocardial infarction (MI)ST-segment myocardial infarction (STEMI)

Identifiers

PMID29404349
PMCPMC5787715
OpenAlexW2767357444

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.