Evidence map›Paper›PMID 29404323›Full record

ArticleFrontiers in bioengineering and biotechnology2018

MicroRNA-146a Regulates Perfusion Recovery in Response to Arterial Occlusion

Joshua L Heuslein, Stephanie P McDonnell, Ji Song, Brian H Annex, Richard J Price

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
16.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 191 citations in OpenAlex.

  1. Trial
  2. MicroRNA Profiling in Chronic Limb-Threatening Ischemia Their Role in Arteriogenesis.The International journal of angiology : official publication of the International College of Angiology, Inc · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. The Role of Circulating Biomarkers in Peripheral Arterial Disease.International journal of molecular sciences · 2021
    Review
  9. Noncoding RNAs in Critical Limb Ischemia.Arteriosclerosis, thrombosis, and vascular biology · 2020
    Review
  10. Review
  11. Review
  12. Applications of Ultrasound to Stimulate Therapeutic Revascularization.International journal of molecular sciences · 2019
    Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Joshua L HeusleinDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States.
Stephanie P McDonnellRobert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, United States.
Ji SongDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States.
Brian H AnnexDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States.
Richard J PriceDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States.
University of Virginia · US

Funding

BASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6M
Systems Biology of Angiogenesis in Peripheral Arterial DiseaseR01HL101200 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POPEL, ALEKSANDER S. · 2010 to 2022
$10.7M
A Bioengineering Approach to Gene Therapy for Peripheral Arterial DiseaseR01HL116455 · NHLBI · UNIVERSITY OF VIRGINIA · PI ANNEX, BRIAN H, FRENCH, BRENT A · 2014 to 2017
$2.7M
MRI-Guided miRNA Nanoparticle Delivery to Glioblastoma With Focused UltrasoundR01EB020147 · NIBIB · UNIVERSITY OF VIRGINIA · PI HANES, JUSTIN S., PRICE, RICHARD J. · 2015 to 2018
$2.4M
MicroRNA 93 in Peripheral Arterial DiseaseR01HL121635 · NHLBI · UNIVERSITY OF VIRGINIA · PI ANNEX, BRIAN H · 2014 to 2017
$1.6M
Endothelial DNA Methylation, Arteriogenic Capacity, and Shear Stress "Set-Point."R21EB024323 · NIBIB · UNIVERSITY OF VIRGINIA · PI PRICE, RICHARD J. · 2017 to 2018
$442k
Application of Laser Speckle Flowmetry to Vascular RemodelingR03EB017927 · NIBIB · UNIVERSITY OF VIRGINIA · PI PRICE, RICHARD J. · 2014 to 2015
$153k
NHLBI NIH HHS R01 HL101200NHLBI NIH HHS R01 HL116455NHLBI NIH HHS R01 HL121635NHLBI NIH HHS T32 HL007284NIBIB NIH HHS R01 EB020147NIBIB NIH HHS R03 EB017927NIBIB NIH HHS R21 EB024323
6 · The paper itself

Abstract

The growth of endogenous collateral arteries that bypass arterial occlusion(s), or arteriogenesis, is a fundamental shear stress-induced adaptation with implications for treating peripheral arterial disease. MicroRNAs (miRs) are key regulators of gene expression in response to injury and have strong therapeutic potential. In a previous study, we identified miR-146a as a candidate regulator of vascular remodeling. Here, we tested whether miR-146a regulates

Indexed as

angiogenesisarteriogenesisendothelial cellepigeneticshindlimb ischemiamicroRNAperipheral arterial diseaseshear stress

Identifiers

PMID29404323
PMCPMC5786509
OpenAlexW2791142181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.