Evidence map›Paper›PMID 29404056›Full record

ArticleJournal of pharmaceutical analysis2017

Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor.

Gema M Durán, Tomás E Benavidez, Ana M Contento, Angel Ríos, Carlos D García

Open access · goldAbstract read
In one paragraph

Article in Journal of pharmaceutical analysis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
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  4. Selective dual sensing strategy for free and vitamin DAnalytical and bioanalytical chemistry · 2024
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  5. Bimetallic FeOMikrochimica acta · 2024
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Gema M DuránDepartment of Analytical Chemistry and Food Technology, University of Castilla-La Mancha, Camilo José Cela Av., Ciudad Real E 13004, Spain.
Tomás E BenavidezDepartment of Chemistry, Clemson University, 219 Hunter Laboratories, Clemson, SC 29634, USA.
Ana M ContentoDepartment of Analytical Chemistry and Food Technology, University of Castilla-La Mancha, Camilo José Cela Av., Ciudad Real E 13004, Spain.
Angel RíosDepartment of Analytical Chemistry and Food Technology, University of Castilla-La Mancha, Camilo José Cela Av., Ciudad Real E 13004, Spain.
Carlos D GarcíaDepartment of Chemistry, Clemson University, 219 Hunter Laboratories, Clemson, SC 29634, USA.
University of Castilla-La Mancha · ESClemson University · US

Funding

RCMI Center for Interdiscplinary Health Research CIHRG12MD007591 · NIMHD · UNIVERSITY OF TEXAS SAN ANTONIO · PI PERRY, GEORGE · 2012 to 2016
$10.4M
NIMHD NIH HHS G12 MD007591
6 · The paper itself

Abstract

A simple methodology was developed to quantify penicillamine (PA) in pharmaceutical samples, using the selective interaction of the drug with Cu-modified graphene quantum dots (Cu-GQDs). The proposed strategy combines the advantages of carbon dots (over other nanoparticles) with the high affinity of PA for the proposed Cu-GQDs, resulting in a significant and selective quenching effect. Under the optimum conditions for the interaction, a linear response (in the 0.10-7.50 µmol/L PA concentration range) was observed. The highly fluorescent GQDs used were synthesized using uric acid as single precursor and then characterized by high resolution transmission electron microscopy, Raman spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, fluorescence, and absorption spectroscopy. The proposed methodology could also be extended to other compounds, further expanding the applicability of GQDs.

Indexed as

Fluorescence quenchingGraphene quantum dotsOne-step synthesisPenicillaminePharmaceutical preparations

Identifiers

PMID29404056
PMCPMC5790703
OpenAlexW2724152241

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.