ReviewJournal of pharmaceutical analysis2016
Selection of appropriate analytical tools to determine the potency and bioactivity of antibiotics and antibiotic resistance.
Review in Journal of pharmaceutical analysis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Comparative validation of LC-MS, micro-bioassay, and ELISA for lincomycin quantification: application to pharmacokinetic analysis in healthy and co-infected porcine models.The veterinary quarterly · 2026Article
- Antibacterial, Antioxidant, and Anti-Inflammatory Activities of Thai Stingless Bee Propolis Extracts.Biology · 2026Article
- Tuning Anticancer Activity and Antimicrobial Response of ZnO Nanoparticles Through Halogenosilane Surface Modification.International journal of molecular sciences · 2026Article
- Dual Analytical Evaluation of Generic Intravenous Vancomycin HCl in Saudi Arabia Using Microbiological and HPLC-DAD Approaches.Antibiotics (Basel, Switzerland) · 2026Article
- Enhancing antibiotic therapy through comprehensive pharmacokinetic/pharmacodynamic principles.Frontiers in cellular and infection microbiology · 2025Review
- Efficacy of BioMin F and NovaMin toothpastes against streptococcus mutans: an in vitro study.BDJ open · 2024Article
- Controlled Sr(ii) ion release fromRSC advances · 2024Article
- Discovery of Melittin as Triple-Action Agent: Broad-Spectrum Antibacterial, Anti-Biofilm, and Potential Anti-Quorum Sensing Activities.Molecules (Basel, Switzerland) · 2024Article
- Shotgun Metagenomics-Guided Prediction Reveals the Metal Tolerance and Antibiotic Resistance of Microbes in Poly-Extreme Environments in the Danakil Depression, Afar Region.Antibiotics (Basel, Switzerland) · 2023Article
- Phenotypic and Genotypic Comparison of Antimicrobial-Resistant Variants ofPharmaceuticals (Basel, Switzerland) · 2023Article
- Recent Advances on Cell Culture Platforms for In Vitro Drug Screening and Cell Therapies: From Conventional to Microfluidic Strategies.Advanced healthcare materials · 2023Review
- Culturing the Human Oral Microbiota, Updating Methodologies and Cultivation Techniques.Microorganisms · 2023Review
- Purification and Characterization of Novel Anti-MRSA Peptides Produced byMolecules (Basel, Switzerland) · 2022Article
- Erythromycin Formulations-A Journey to Advanced Drug Delivery.Pharmaceutics · 2022Review
- Application of an Ultrasonic Nebulizer Closet in the Disinfection of Textiles and Footwear.International journal of environmental research and public health · 2022Article
- Genome plasticity as a paradigm of antibiotic resistance spread in ESKAPE pathogens.Environmental science and pollution research international · 2022Review
- A Critical Review of the Antimicrobial and Antibiofilm Activities of Green-Synthesized Plant-Based Metallic Nanoparticles.Nanomaterials (Basel, Switzerland) · 2022Review
- Coexistence of Heavy Metal Tolerance and Antibiotic Resistance in Thermophilic Bacteria Belonging to GenusFrontiers in microbiology · 2022Article
- Quercetin-Crosslinked Chitosan Films for Controlled Release of Antimicrobial Drugs.Frontiers in bioengineering and biotechnology · 2022Article
- Effects of hydrolyzable tannin extract obtained from sweet chestnut wood (Veterinary world · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotics are the chemotherapeutic agents that kill or inhibit the pathogenic microorganisms. Resistance of microorganism to antibiotics is a growing problem around the world due to indiscriminate and irrational use of antibiotics. In order to overcome the resistance problem and to safely use antibiotics, the correct measurement of potency and bioactivity of antibiotics is essential. Microbiological assay and high performance liquid chromatography (HPLC) method are used to quantify the potency of antibiotics. HPLC method is commonly used for the quantification of potency of antibiotics, but unable to determine the bioactivity; whereas microbiological assay estimates both potency and bioactivity of antibiotics. Additionally, bioassay is used to estimate the effective dose against antibiotic resistant microbes. Simultaneously, microbiological assay addresses the several parameters such as minimal inhibitory concentration (MIC), minimum bactericidal concentration (MBC), mutation prevention concentration (MPC) and critical concentration (Ccr) which are used to describe the potency in a more informative way. Microbiological assay is a simple, sensitive, precise and cost effective method which gives reproducible results similar to HPLC. However, the HPLC cannot be a complete substitute for microbiological assay and both methods have their own significance to obtain more realistic and precise results.
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Registered trials
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