Evidence map›Paper›PMID 29403951›Full record

ArticleJournal of pharmaceutical analysis2015

Quantification of tolvaptan in rabbit plasma by LC-MS/MS: Application to a pharmacokinetic study.

Kumar S Moola, Bala Sekhara Reddy Challa, Chandrasekhar Kothapalli Bannoth

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmaceutical analysis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kumar S MoolaARPL Pvt. Ltd., Bangalore 560099, India.
Bala Sekhara Reddy ChallaVagdevi College of Pharmacy, Gurazala, Andhra Pradesh 522415, India.
Chandrasekhar Kothapalli BannothJawaharlal Nehru Technological University, Anantapur, Andhra Pradesh 522001, India.
Jawaharlal Nehru Technological University Anantapur · INSri Ganapathi Sachchidananda Vagdevi Center · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A sensitive, selective and high-throughput liquid chromatography-tandem mass spectrometry (LC-ESI-MS/MS) method was developed and validated for the quantitation of tolvaptan in rabbit plasma. Sample clean-up involved liquid-liquid extraction (LLE) and chromatography was performed on Zorbax SB C

Indexed as

LC–ESI–MS/MSLiquid–liquid extractionPharmacokineticsRabbit plasmaTolvaptan

Identifiers

PMID29403951
PMCPMC5762243
OpenAlexW2090331081

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.