Evidence map›Paper›PMID 29403858›Full record

ArticleJournal of pharmaceutical analysis2013

Method development and validation of Guanfacine in rat plasma by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study.

Suryanarayana Murthy Goparaju, Yadagiri Srinivasa Murthy Nandula, Chandrasekher Bannoth Kothapalli, B R Challa, Bahlul Z Awen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmaceutical analysis, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Suryanarayana Murthy GoparajuJawaharlal Nehru Technological University, Anantapur, Andhra Pradesh 522001, India.
Yadagiri Srinivasa Murthy NandulaC.V.S.R College of Engineering, Hyderabad, India.
Chandrasekher Bannoth KothapalliJawaharlal Nehru Technological University, Anantapur, Andhra Pradesh 522001, India.
B R ChallaNirmala College of Pharmacy, Madras Road, Kadapa, Andhra Pradesh 516002, India.
Bahlul Z AwenFaculty of Pharmacy, Tripoli University, Libya.
Jawaharlal Nehru Technological University Anantapur · INNirma (India) · INUniversity of Tripoli · LY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A selective, sensitive and high-throughput liquid chromatography-tandem mass spectrometry (LC-ESI-MS/MS) method has been developed and validated for the quantitation of Guanfacine in rat plasma. Sample clean-up involved liquid-liquid extraction (LLE) and 100 μL of rat plasma was used. YMC BASIC column (50 mm×2.0 mm, 3.5 µm) was used. Mobile phase used was 10 mM ammonium formate (pH 4.0):acetonitrile (70:30, v/v) at a flow rate of 0.3 mL/min. The parent→product ion transitions for the drug (

Indexed as

GuanfacineLC–ESI-MS/MSLiquid–liquid extractionPharmacokinetic studyRat plasma

Identifiers

PMID29403858
PMCPMC5760995
OpenAlexW2027956696

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.