Evidence map›Paper›PMID 29403549›Full record

ArticleExperimental and therapeutic medicine2018

Observational analysis on inflammatory reaction to talc pleurodesis: Small and large animal model series review.

Jacopo Vannucci, Guido Bellezza, Alberto Matricardi, Giulia Moretti, Antonello Bufalari, Lucio Cagini, Francesco Puma, Niccolò Daddi

Abstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jacopo VannucciDepartment of Thoracic Surgery, University of Perugia Medical School, I-06134 Perugia, Italy.
Guido BellezzaInstitute of Pathological Anatomy and Histology, University of Perugia Medical School, I-06134 Perugia, Italy.
Alberto MatricardiDepartment of Thoracic Surgery, University of Perugia Medical School, I-06134 Perugia, Italy.
Giulia MorettiDepartment of Veterinary Medicine, University of Perugia, I-06134 Perugia, Italy.
Antonello BufalariDepartment of Veterinary Medicine, University of Perugia, I-06134 Perugia, Italy.
Lucio CaginiDepartment of Thoracic Surgery, University of Perugia Medical School, I-06134 Perugia, Italy.
Francesco PumaDepartment of Thoracic Surgery, University of Perugia Medical School, I-06134 Perugia, Italy.
Niccolò DaddiThoracic Surgery, Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of Bologna, I-40126 Bologna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Talc pleurodesis has been associated with pleuropulmonary damage, particularly long-term damage due to its inert nature. The present model series review aimed to assess the safety of this procedure by examining inflammatory stimulus, biocompatibility and tissue reaction following talc pleurodesis. Talc slurry was performed in rabbits: 200 mg/kg checked at postoperative day 14 (five models), 200 mg/kg checked at postoperative day 28 (five models), 40 mg/kg, checked at postoperative day 14 (five models), 40 mg/kg checked at postoperative day 28 (five models). Talc poudrage was performed in pigs: 55 mg/kg checked at postoperative day 60 (18 models). Tissue inspection and data collection followed the surgical pathology approach currently used in clinical practice. As this was an observational study, no statistical analysis was performed. Regarding the rabbit model (

Indexed as

animal modelmalignant effusionpleural diseasepleuritispleurodesispleuropulmonarypneumothoraxpoudrageslurrytalc

Identifiers

PMID29403549
PMCPMC5780742

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.