Evidence map›Paper›PMID 29403484›Full record

ArticleFrontiers in immunology2017

Reduced Expression of Membrane Complement Regulatory Protein CD59 on Leukocytes following Lung Transplantation.

Laura A Michielsen, Kevin Budding, Daniël Drop, Ed A van de Graaf, Tineke Kardol-Hoefnagel, Marianne C Verhaar, Arjan D van Zuilen, Henny G Otten

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Laura A MichielsenDepartment of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Kevin BuddingLaboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Daniël DropLaboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Ed A van de GraafDepartment of Respiratory Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Tineke Kardol-HoefnagelLaboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Marianne C VerhaarDepartment of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Arjan D van ZuilenDepartment of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Henny G OttenLaboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
University Medical Center Utrecht · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular protection against undesired effects of complement activation is provided by expression of membrane-bound complement regulatory proteins including CD59. This protein prevents membrane attack complex formation and is considered to be involved in graft accommodation. Also, CD59 downregulates CD4+ and CD8+ T-cell activation and proliferation. It is unknown whether CD59 expression is affected by transplantation. The aim of this study was to evaluate the quantitative CD59 antigen expression on distinct leukocyte subsets following lung transplantation (

Indexed as

accommodationCD59complementlung transplantationlymphocyte biology

Identifiers

PMID29403484
PMCPMC5786830
OpenAlexW2791156192

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.