Evidence map›Paper›PMID 29403471›Full record

ArticleFrontiers in immunology2017

Immune Tolerance to Apoptotic Self Is Mediated Primarily by Regulatory B1a Cells.

Katherine Miles, Joanne Simpson, Sheila Brown, Graeme Cowan, David Gray, Mohini Gray

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Article
  3. A distinct TCRiScience · 2026
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  13. Innate B Cells: the Archetype of Protective Immune Cells.Clinical reviews in allergy & immunology · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Katherine MilesMRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Joanne SimpsonMRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Sheila BrownSchool of Biological Sciences, Institute of Immunology and Infection Research, Ashworth Laboratories, The University of Edinburgh, Edinburgh, United Kingdom.
Graeme CowanSchool of Biological Sciences, Institute of Immunology and Infection Research, Ashworth Laboratories, The University of Edinburgh, Edinburgh, United Kingdom.
David GraySchool of Biological Sciences, Institute of Immunology and Infection Research, Ashworth Laboratories, The University of Edinburgh, Edinburgh, United Kingdom.
Mohini GrayMRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
University of Edinburgh · GB

Funding

Cancer Research UK 20035Medical Research Council G0901697Medical Research Council MR/J009555/1
6 · The paper itself

Abstract

The chronic autoimmune inflammatory diseases, systemic lupus erythematosus and Sjogren's syndrome, develop when tolerance to apoptotic cells (ACs) is lost. We have previously reported that this tolerance is maintained by innate-like, IL-10 secreting regulatory B cells. Two questions remained. First, do these regulatory B cells belong predominantly to a single subset of steady-state B cells and second, what is their specificity? We report here that innate-like B cells with markers characteristic for B1a cells (CD43

Indexed as

apoptotic cellB1aB cellimmune toleranceregulatory

Identifiers

PMID29403471
PMCPMC5780629
OpenAlexW2785147419

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.