ReviewFrontiers in endocrinology2017
From Diabetes Care to Diabetes Cure-The Integration of Systems Biology, eHealth, and Behavioral Change.
Review in Frontiers in endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- The effect of personalized intelligent digital systems for self-care training on type II diabetes: a systematic review and meta-analysis of clinical trials.Acta diabetologica · 2023Pooled it
- Metabolic impact of intermittent energy restriction and periodic fasting in patients with type 2 diabetes: a systematic review.Nutrition reviews · 2023Pooled it
- Personalisation of the Dutch combined lifestyle intervention SLIMMER improves participant retention and weight loss in people at risk for cardiometabolic disease.Scientific reports · 2025Trial
- Evaluation of Food-Intake Behavior in a Healthy Population: Personalized vs. One-Size-Fits-All.Nutrients · 2020Trial
- "An illustrative socio-biological cascade of the concentric model for health-bound networks: social determinants, social support and biological responses".Frontiers in systems biology · 2026Article
- Prediabetes Awareness Barriers and Enablers: National Health and Nutrition Examination Survey 2011-2020.AJPM focus · 2025Article
- Exploring the Link Between Demographic, Employment, and Coaching Characteristics With Financial Earning Among Health and Wellness Coaches.American journal of lifestyle medicine · 2025Article
- Implementing Lifestyle Counselling Into Secondary Type 2 Diabetes Care: Perspectives From Diabetes Nurses.Nursing open · 2025Article
- Pathophysiological hallmarks in type 2 diabetes heterogeneity (review).Diabetology international · 2025Review
- Exploring the Acceptance of Just-in-Time Adaptive Lifestyle Support for People With Type 2 Diabetes: Qualitative Acceptability Study.JMIR formative research · 2025Article
- Complete Lifestyle Medicine Intervention Program-Ontario: Implementation Protocol for a Rural Study.JMIR research protocols · 2024Article
- Differential impact of lifestyle factors on 2-hour glucose values in individuals with type 2 diabetes: potential for more personalized interventions.BMJ open diabetes research & care · 2024Article
- The impact of the multicomponent "Healthy and Vital" 3-month lifestyle intervention in health professionals: a single group pre-(multiple) post-study.BMC health services research · 2024Article
- Explain the behavior change and maintenance in diabetic patients using MTM-HAPA framework.Frontiers in psychiatry · 2024Article
- 360° Diagnostic Tool to Personalize Lifestyle Advice in Primary Care for People With Type 2 Diabetes: Development and Usability Study.JMIR formative research · 2023Article
- A Digital Lifestyle Coach (E-Supporter 1.0) to Support People With Type 2 Diabetes: Participatory Development Study.JMIR human factors · 2023Article
- A network perspective on the ecology of gut microbiota and progression of type 2 diabetes: Linkages to keystone taxa in a Mexican cohort.Frontiers in endocrinology · 2023Article
- A Mini-Review of Current Treatment Approaches and Gene Therapy as Potential Interventions for Diabetes Mellitus Types 1.Advanced biomedical research · 2023Review
- Digital Biomarkers for Personalized Nutrition: Predicting Meal Moments and Interstitial Glucose with Non-Invasive, Wearable Technologies.Nutrients · 2022Article
- A scoping review of systems approaches for increasing physical activity in populations.Health research policy and systems · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
From a biological view, most of the processes involved in insulin resistance, which drives the pathobiology of type 2 diabetes, are reversible. This theoretically makes the disease reversible and curable by changing dietary habits and physical activity, particularly when adopted early in the disease process. Yet, this is not fully implemented and exploited in health care due to numerous obstacles. This article reviews the state of the art in all areas involved in a diabetes cure-focused therapy and discusses the scientific and technological advancements that need to be integrated into a systems approach sustainable lifestyle-based healthcare system and economy. The implementation of lifestyle as cure necessitates personalized and sustained lifestyle adaptations, which can only be established by a systems approach, including all relevant aspects (personalized diagnosis and diet, physical activity and stress management, self-empowerment, motivation, participation and health literacy, all facilitated by blended care and ehealth). Introduction of such a systems approach in type 2 diabetes therapy not only requires a concerted action of many stakeholders but also a change in healthcare economy, with new winners and losers. A "call for action" is put forward to actually initiate this transition. The solution provided for type 2 diabetes is translatable to other lifestyle-related disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.