ArticleFrontiers in neurology2017
Blood Glutamate Levels Are Closely Related to Acute Lung Injury and Prognosis after Stroke.
Article in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Immunomodulation for stroke-associated pneumonia: a systematic review of mechanistic insight and emerging therapeutic strategies in animal models.Frontiers in immunology · 2026Pooled it
- A systematic review of biomarkers multivariately associated with acute respiratory distress syndrome development and mortality.Critical care (London, England) · 2020Pooled it
- PKM2 from hyperactive neuron aggravate lung injury post-stroke by promoting FOXO3A/TXNIP mitochondria translocation in mice.Redox biology · 2026Article
- Ischemic stroke neuroprotection revisited: translational barriers and a phase-resolved, biomarker-anchored framework.Archives of pharmacal research · 2026Review
- Stroke and Distal Organ Damage: Exploring Brain-Kidney Crosstalk.Neurochemical research · 2024Review
- Causal effect of COVID-19 on optic nerve and visual pathway disorders: genetic evidence of lung-brain axis.Frontiers in immunology · 2024Article
- Functional Two-Way Crosstalk Between Brain and Lung: The Brain-Lung Axis.Cellular and molecular neurobiology · 2023Review
- Biomarkers and the outcomes of ischemic stroke.Frontiers in molecular neuroscience · 2023Review
- Evaluation and Characterization of Post-Stroke Lung Damage in a Murine Model of Cerebral Ischemia.International journal of molecular sciences · 2022Article
- Brain to periphery in acute ischemic stroke: Mechanisms and clinical significance.Frontiers in neuroendocrinology · 2021Review
- Pulmonary infection induces persistent, pathogen-specific lipidomic changes influencing trained immunity.iScience · 2021Article
- Pinocembrin attenuates hemorrhagic transformation after delayed t-PA treatment in thromboembolic stroke rats by regulating endogenous metabolites.Acta pharmacologica Sinica · 2021Article
- Stroke-induced immunosuppression: implications for the prevention and prediction of post-stroke infections.Journal of neuroinflammation · 2021Review
- NMDA receptor modulation and severe acute respiratory syndrome treatment.F1000Research · 2021Article
- Dynamic Process of Secondary Pulmonary Infection in Mice With Intracerebral Hemorrhage.Frontiers in immunology · 2021Article
- Ischaemic stroke-induced distal organ damage: pathophysiology and new therapeutic strategies.Intensive care medicine experimental · 2020Review
- Ischaemic stroke in mice induces lung inflammation but not acute lung injury.Scientific reports · 2019Article
- Inhibition of CD147 Attenuates Stroke-Associated Pneumonia Through Modulating Lung Immune Response in Mice.Frontiers in neurology · 2019Article
- Focal ischemic stroke leads to lung injury and reduces alveolar macrophage phagocytic capability in rats.Critical care (London, England) · 2018Article
- Intensive versus standard statin therapy in acute ischemic stroke: a comparative study on the risk of pneumonia and multidrug-resistant bacterial infections.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute lung injury (ALI) is a serious complication of stroke that occurs with a high incidence. Our preclinical results indicated that ALI might be related to blood glutamate levels after brain injury. The purpose of this study was to assess dynamic changes in blood glutamate levels in patients with stroke and to determine the correlation between blood glutamate levels, ALI, and long-term prognosis after stroke.
methodsVenous blood samples were collected from controls and patients with stroke at admission and on the third and seventh day after the onset of stroke. Patients were followed for 3 months. The correlations among blood glutamate levels, severities of stroke and ALI, and long-term outcomes were analyzed, and the predictive values of blood glutamate levels and severity scores for ALI were assessed.
resultsIn this study, a total of 384 patients with stroke were enrolled, with a median age of 59 years. Patients showed significantly increased blood glutamate levels within 7 days of stroke onset (
conclusionThese results indicated that an increased blood glutamate level was closely related to the development of ALI and a poor prognosis after stroke. CLINICAL
trial registrationhttp://www.chictr.org.cn, identifier ChiCTR-RPC-15006770.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.