Evidence map›Paper›PMID 29403390›Full record

ReviewFrontiers in physiology2018

Fatty Infiltration of the Myocardium and Arrhythmogenesis:

Justus M B Anumonwo, Todd Herron

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 51 citations in OpenAlex.

  1. Obesity Arrhythmias: Role of IL-6 Trans-Signaling.International journal of molecular sciences · 2024
    Review
  2. Central Obesity is Associated with Increased Left Ventricular Maximal Wall Thickness and Intrathoracic Adipose Tissue Measured with Cardiac Magnetic Resonance.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2024
    Article
  3. Article
  4. Article
  5. Review
  6. Cardiac Adipose Tissue Segmentation via Image-Level Annotations.IEEE journal of biomedical and health informatics · 2023
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Epicardial adipose tissue as a mediator of cardiac arrhythmias.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  16. Article
  17. Review
  18. Review
  19. Cardiac Adiposity and Arrhythmias: The Role of Imaging.Diagnostics (Basel, Switzerland) · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Justus M B AnumonwoDepartment of Internal Medicine (Cardiovascular Medicine), Center for Arrythmia Research, University of Michigan, Ann Arbor, MI, United States.
Todd HerronDepartment of Internal Medicine (Cardiovascular Medicine), Center for Arrythmia Research, University of Michigan, Ann Arbor, MI, United States.
University of Michigan–Ann Arbor · US

Funding

Arrhythmogenicity of human SAP97 Mutations in patient specific iPSC-CMs and MiceR01HL124319 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANUMONWO, JUSTUS M · 2015 to 2017
$1.3M
NHLBI NIH HHS R01 HL124319
6 · The paper itself

Abstract

Anatomical evidence in several species shows highly heterogeneous fat distribution in the atrial and ventricular myocardium. Atrial appendages have fat deposits, and more so on the posterior left atrium. Although such fat distributions are considered normal, fatty infiltration is regarded arrhythmogenic, and various cardiac pathophysiological conditions show excess myocardial fat deposits, especially in the epicardium. Hypotheses have been presented for the physiological and pathophysiological roles of epicardial fat, however this issue is poorly understood. Therefore, this mini-review will focus on epicardial fat distribution and the (patho)-physiological implications of this distribution. Potential molecular mechanisms that may drive structural and electrical myocardial remodeling attendant to fatty infiltration of the heart are also reviewed.

Indexed as

cardiac arrhythmiasepicardial adiposityfatty infiltrationmyocardial remodelingobesity

Identifiers

PMID29403390
PMCPMC5786512
OpenAlexW2788776197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.