ReviewFrontiers in physiology2017
Spinal Health during Unloading and Reloading Associated with Spaceflight.
Review in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cervical Intervertebral Disc Expansion, Vertebral Compliance Reduction and Neck Pain is Induced by 4h of Hyper-buoyancy Flotation That is Only Partially Reversed by 15 Mins 1g Re-loading
Acute 50% Body Weight Static Axial Loading Reverses Stature Increases, Lumbar Disc Expansion and Vertebral Compliance Modulation Induced by 4 Hours of Hyper-buoyancy Floatation
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Optimizing healthcare in space: the role of ultrasound imaging in medical conditions.Journal of ultrasound · 2024Pooled it
- Introducing the Concept of Exercise Holidays for Human Spaceflight - What Can We Learn From the Recovery of Bed Rest Passive Control Groups.Frontiers in physiology · 2022Pooled it
- DI-5-Cuffs: Lumbar Intervertebral Disc Proteoglycan and Water Content Changes in Humans after Five Days of Dry Immersion to Simulate Microgravity.International journal of molecular sciences · 2020Trial
- Hyper-buoyancy flotation increases cervical disc height and reduces vertebral stiffness, with only partial reversal after acute 1 g axial loading.Experimental physiology · 2026Article
- 50% body weight loading reduces stature increases and lumbar disc expansion from 4 h hyper-buoyancy floatation versus 15 min sitting upright.Experimental physiology · 2026Article
- Entering a new era for exercise countermeasures in human spaceflight.Experimental physiology · 2026Article
- A systematic review identifying fitness metrics indicative of simulated astronaut extravehicular activity task performance.NPJ microgravity · 2026Article
- Microgravity-induced transcriptional reprogramming in embryonic chicken limb bud-derived chondrogenic cultures.Frontiers in cell and developmental biology · 2026Article
- Numerical study on the effect of microgravity on biomechanics in human lumbar intervertebral discs.NPJ microgravity · 2025Article
- Do we know more about the mechanobiology of the intervertebral disc in space than on Earth?JOR spine · 2025Article
- Adaptation of thoracic and lumbar curvature and spinal muscle activity under changing gravity.Frontiers in physiology · 2025Article
- Validity & Reliability of Using Musculoskeletal Ultrasound to Measure Cervical Disc Height.International journal of sports physical therapy · 2025Article
- Muscle stiffness indicating mission crew health in space.Scientific reports · 2024Article
- Lunar and mars gravity induce similar changes in spinal motor control as microgravity.Frontiers in physiology · 2023Article
- Microgravity and the intervertebral disc: The impact of space conditions on the biomechanics of the spine.Frontiers in physiology · 2023Review
- Pain Experience and Sensory Changes in Astronauts During and After Short-Lasting Commercial Spaceflight: A Proof-of-Concept Study.Journal of pain research · 2023Article
- To infinity and beyond: Strategies for fabricating medicines in outer space.International journal of pharmaceutics: X · 2022Article
- Article
- Effect of trunk exercise upon lumbar IVD height and vertebral compliance when performed supine with 1 g at the CoM compared to upright in 1 g.BMC sports science, medicine & rehabilitation · 2022Article
- Comparison of trunk muscle exercises in supine position during short arm centrifugation with 1 g at centre of mass and upright in 1 g.Frontiers in physiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal elongation and back pain are recognized effects of exposure to microgravity, however, spinal health has received relatively little attention. This changed with the report of an increased risk of post-flight intervertebral disc (IVD) herniation and subsequent identification of spinal pathophysiology in some astronauts post-flight. Ground-based analogs, particularly bed rest, suggest that a loss of spinal curvature and IVD swelling may be factors contributing to unloading-induced spinal elongation. In flight, trunk muscle atrophy, in particular
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.