Evidence map›Paper›PMID 29403388›Full record

ArticleFrontiers in physiology2017

Differences in Contractile Function of Myofibrils within Human Embryonic Stem Cell-Derived Cardiomyocytes vs. Adult Ventricular Myofibrils Are Related to Distinct Sarcomeric Protein Isoforms.

Bogdan Iorga, Kristin Schwanke, Natalie Weber, Meike Wendland, Stephan Greten, Birgit Piep, Cristobal G Dos Remedios, Ulrich Martin, Robert Zweigerdt, Theresia Kraft and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
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  7. Review
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  9. Review
  10. Why make a strong muscle weaker?The Journal of general physiology · 2021
    Article
  11. Hypertrophic cardiomyopathy β-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  12. Review
  13. Review
  14. Force Measurements From Myofibril to Filament.Frontiers in physiology · 2021
    Review
  15. Article
  16. hiPSC-Derived Cardiac Tissue for Disease Modeling and Drug Discovery.International journal of molecular sciences · 2020
    Review
  17. Optimizing the Use of iPSC-CMs for Cardiac Regeneration in Animal Models.Animals : an open access journal from MDPI · 2020
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

Bogdan IorgaDepartment of Molecular and Cell Physiology, Hannover Medical School, Hannover, Germany.
Kristin SchwankeDepartment of Cardiac, Thoracic, Transplantation and Vascular Surgery, Leibniz Research Laboratories for Biotechnology and Artificial Organs, REBIRTH-Center for Regenerative Medicine, Hannover Medical School, Hannover, Germany.
Natalie WeberDepartment of Molecular and Cell Physiology, Hannover Medical School, Hannover, Germany.
Meike WendlandDepartment of Molecular and Cell Physiology, Hannover Medical School, Hannover, Germany.
Stephan GretenDepartment of Molecular and Cell Physiology, Hannover Medical School, Hannover, Germany.
Birgit PiepDepartment of Molecular and Cell Physiology, Hannover Medical School, Hannover, Germany.
Cristobal G Dos RemediosDepartment of Anatomy, Bosch Institute, University of Sydney, Sydney, NSW, Australia.
Ulrich MartinDepartment of Cardiac, Thoracic, Transplantation and Vascular Surgery, Leibniz Research Laboratories for Biotechnology and Artificial Organs, REBIRTH-Center for Regenerative Medicine, Hannover Medical School, Hannover, Germany.
Robert ZweigerdtDepartment of Cardiac, Thoracic, Transplantation and Vascular Surgery, Leibniz Research Laboratories for Biotechnology and Artificial Organs, REBIRTH-Center for Regenerative Medicine, Hannover Medical School, Hannover, Germany.
Theresia KraftDepartment of Molecular and Cell Physiology, Hannover Medical School, Hannover, Germany.
Bernhard BrennerDepartment of Molecular and Cell Physiology, Hannover Medical School, Hannover, Germany.
Medizinische Hochschule Hannover · DERobert Bosch (Australia) · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Characterizing the contractile function of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is key for advancing their utility for cellular disease models, promoting cell based heart repair, or developing novel pharmacological interventions targeting cardiac diseases. The aim of the present study was to understand whether steady-state and kinetic force parameters of β-myosin heavy chain (βMyHC) isoform-expressing myofibrils within human embryonic stem cell-derived cardiomyocytes (hESC-CMs) differentiated

Indexed as

adult human ventricular myofibrilscardiac contractile functioncross-bridge kineticshiPSC-CMs maturationhuman cardiomyocytes developmenthuman embryonic stem cell-derived cardiomyocyteshuman pluripotent stem cell-derived cardiomyocytesβ-myosin isoform cross-bridge

Identifiers

PMID29403388
PMCPMC5780405
OpenAlexW2789269245

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.