ArticleFrontiers in neuroscience2018
Peripheral Neuron Survival and Outgrowth on Graphene.
Article in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 citations in OpenAlex.
- Using transient, effector-specific neural responses to gate decoding for brain-computer interfaces.Journal of neural engineering · 2025Trial
- Non-genetic neuromodulation with graphene optoelectronic actuators for disease models, stem cell maturation, and biohybrid robotics.Nature communications · 2025Article
- The dual roles of chemokines in peripheral nerve injury and repair.Inflammation and regeneration · 2025Review
- Engineered Graphene Material Improves the Performance of Intraneural Peripheral Nerve Electrodes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Graphene-based nanomaterials for peripheral nerve regeneration.Frontiers in bioengineering and biotechnology · 2023Review
- The mechanical, optical, and thermal properties of graphene influencing its pre-clinical use in treating neurological diseases.Frontiers in neuroscience · 2023Review
- An Insight of Nanomaterials in Tissue Engineering from Fabrication to Applications.Tissue engineering and regenerative medicine · 2022Review
- Application of Graphene in Tissue Engineering of the Nervous System.International journal of molecular sciences · 2021Review
- Novel Graphene Electrode for Retinal Implants: AnFrontiers in neuroscience · 2021Article
- Graphene Nanoplatelets Render Poly(3-Hydroxybutyrate) a Suitable Scaffold to Promote Neuronal Network Development.Frontiers in neuroscience · 2021Article
- Atomic Details of Carbon-Based Nanomolecules Interacting with Proteins.Molecules (Basel, Switzerland) · 2020Review
- PC12 Cell Line: Cell Types, Coating of Culture Vessels, Differentiation and Other Culture Conditions.Cells · 2020Article
- Effect of Chemical Vapor Deposition WSFrontiers in neuroscience · 2020Article
- Graphene-Based Nanomaterials: From Production to Integration With Modern Tools in Neuroscience.Frontiers in systems neuroscience · 2019Article
- [Research progress of graphene and its derivatives in repair of peripheral nerve defect].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Graphene displays properties that make it appealing for neuroregenerative medicine, yet its interaction with peripheral neurons has been scarcely investigated. Here, we culture on graphene two established models for peripheral neurons: PC12 cells and DRG primary neurons. We perform a nano-resolved analysis of polymeric coatings on graphene and combine optical microscopy and viability assays to assess the material cytocompatibility and influence on differentiation. We find that differentiated PC12 cells display a remarkably increased neurite length on graphene (up to 27%) with respect to controls. Notably, DRG primary neurons survive both on bare and coated graphene. They present dense axonal networks on coated graphene, while they form cell islets characterized by dense axonal bundles on uncoated graphene. These findings indicate that graphene holds potential for nerve tissue regeneration and might pave the road to novel concepts of active nerve conduits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.