ArticleNeuropsychiatric disease and treatment2018
The impact of age of onset on amygdala intrinsic connectivity in major depression.
Article in Neuropsychiatric disease and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Effects of Cortisol Administration on Resting-State Functional Connectivity in Women with Depression.Psychiatry research. Neuroimaging · 2024Trial
- Brain morphometry and connectivity differs between adolescent- and adult-onset major depressive disorder.Depression and anxiety · 2022Article
- Choline elevation in amygdala region at recovery indicates longer survival without depressive episode: a magnetic resonance spectroscopy study.Psychopharmacology · 2021Article
- Repetitive Transcranial Magnetic Stimulation for Adolescent Major Depressive Disorder: A Focus on Neurodevelopment.Frontiers in psychiatry · 2021Review
- Research Review: Brain network connectivity and the heterogeneity of depression in adolescence - a precision mental health perspective.Journal of child psychology and psychiatry, and allied disciplines · 2020Review
- Girls' brain structural connectivity in late adolescence relates to history of depression symptoms.Journal of child psychology and psychiatry, and allied disciplines · 2020Article
- Empirically supported interventions in psychology: contributions of Research Domain Criteria.Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS · 2019Review
- The Association Between Juvenile Onset of Depression and Emotion Regulation Difficulties.Frontiers in psychology · 2019Article
- The brain-adipocyte-gut network: Linking obesity and depression subtypes.Cognitive, affective & behavioral neuroscience · 2018Review
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Authors and funding
7 authors.
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Abstract
backgroundEarly-onset major depressive disorder (EO-MDD), beginning during childhood and adolescence, is associated with more illness burden and a worse prognosis than adult-onset MDD (AO-MDD), but little is known about the neural features distinguishing these subgroup phenotypes. Functional abnormalities of the amygdala are central to major depressive disorder (MDD) neurobiology; therefore, we examined whether amygdala intrinsic connectivity (IC) can differentiate EO-MDD from AO-MDD in a cohort of adult MDD patients. SUBJECTS AND
methodsTwenty-one EO-MDD (age of onset ≤18 years), 31 AO-MDD patients (age of onset ≥19 years), and 19 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (7 minutes). Amygdala seed-based resting-state functional connectivity was compared between groups.
resultsAO-MDD patients showed loss of inverse left amygdala-left dorsolateral prefrontal cortex IC and increased inverse left amygdala-left inferior parietal IC, compared to both HCs and EO-MDD. EO-MDD showed a switch from inverse to positive IC with right dorsomedial prefrontal cortex, compared to HCs and AO-MDD. This effect was removed when we controlled for illness burden.
conclusionAlterations in amygdala IC with the default-mode network were specifically related to EO-MDD, whereas amygdala IC with executive cognitive control regions was preferentially disrupted in AO-MDD. Increased illness burden, an important clinical marker of EO-MDD, accounted for its specific effects on amygdala IC. Brain imaging has the potential for validation of clinical subtypes and can provide markers of prognostic value in MDD patients.
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