ArticleMacromolecules
Self-healing hydrogels formed by complexation between calcium ions and bisphosphonate-functionalized star-shaped polymers.
Article in Macromolecules. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Hydrogel microspheres for precision biomedicine: network engineering, microfabrication, and therapeutic applications.RSC advances · 2026Review
- The Mechanical Reinforcing Mechanism and Self-Healing Properties of Biomimetic Hybrid Cement Composites via In-Situ Polymerization.Materials (Basel, Switzerland) · 2025Article
- The Use of Recycled PET for the Synthesis of New Mechanically Improved PVP Composite Nanofibers.Polymers · 2022Article
- Catalyst-Free Click Chemistry for Engineering Chondroitin Sulfate-Multiarmed PEG Hydrogels for Skin Tissue Engineering.Journal of functional biomaterials · 2022Article
- Fabrication of highly stretchable hydrogel based on crosslinking between alendronates functionalized poly-γ-glutamate and calcium cations.Materials today. Bio · 2022Article
- Engineering the Dynamics of Cell Adhesion Cues in Supramolecular Hydrogels for Facile Control over Cell Encapsulation and Behavior.Advanced materials (Deerfield Beach, Fla.) · 2021Article
- Soft Materials by Design: Unconventional Polymer Networks Give Extreme Properties.Chemical reviews · 2021Review
- Bisphosphonate-based nanocomposite hydrogels for biomedical applications.Bioactive materials · 2020Review
- Physical and Chemical Factors Influencing the Printability of Hydrogel-based Extrusion Bioinks.Chemical reviews · 2020Review
- Molecular design principles of Lysine-DOPA wet adhesion.Nature communications · 2020Article
- Alendronate-Functionalized Poly(2-oxazoline)s with Tunable Affinity for Calcium Cations.Biomacromolecules · 2019Article
- Electrochemical-Mediated Gelation Of Catechol-Bearing Hydrogels Based On Multimodal Crosslinking.Journal of materials chemistry. B · 2019Article
- Injectable alendronate-functionalized GelMA hydrogels for mineralization and osteogenesis.RSC advances · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Star-shaped poly(ethylene glycol) (PEG) chain termini were functionalized with alendronate to create transient networks with reversible crosslinks upon addition of calcium ions. The gelation ability of alendronate-functionalized PEG was greatly dependent on the number of arms and arm molecular weight. After mixing polymer and calcium solutions, the formed hydrogels could be cut and then brought back together without any visible interface. After 2 minutes of contact, their connection was strong enough to allow for stretching without tearing through the previous fracture surface. Oscillatory rheology showed that the hydrogels recovered between 70 and 100% of the original storage and loss modulus after rupture. Frequency sweep measurements revealed a liquid-like behavior at lower frequencies and solid-like at high frequencies. Shifting frequency curves obtained at different calcium and polymer concentrations, all data collapsed in a single common master curve. This time-concentration superposition reveals a common relaxation mechanism intrinsically connected to the calcium-bisphosphonate complexation equilibrium.
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