ArticleNature cell biology2018
Non-invasive perturbations of intracellular flow reveal physical principles of cell organization.
Article in Nature cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
68 citing papers in PubMed, 147 citations in OpenAlex.
- Robust thermometry-imaging down to sub-micrometer or millisecond-resolution by fluorescence lifetime microscopy allows for additional acquisition of multiple imaging channels.Scientific reports · 2026Article
- Active and probe-free intracellular rheology via phase-sensitive thermoviscous flows.PNAS nexus · 2026Article
- Helical opto-thermoviscous flows drive out-of-plane rotation and particle spinning in a highly viscous micro-environment.Light, science & applications · 2026Article
- Tunable 3D optohydrodynamic torques from optical phase gradient-driven colloidal assemblies.Science advances · 2026Article
- A label-free method for measuring the composition of multicomponent biomolecular condensates.Nature chemistry · 2025Article
- Tunable photon-recoil forces and negative torque at flat-top beam edges.Nature communications · 2025Article
- Small-molecule dissolution of stress granules by redox modulation benefits ALS models.Nature chemical biology · 2025Article
- Optical Micromanipulations Based on Model Predictive Control of Thermoviscous Flows.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- A mechanism for MEX-5-driven disassembly of PGL-3/RNA condensates in vitro.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Remote-controlled mechanical and directional motions of photoswitchable DNA condensates.Nature communications · 2025Article
- Measuring and manipulating mechanical forces during development.Nature cell biology · 2025Review
- Dynamic flow control through active matter programming language.Nature materials · 2025Article
- Robust spatiotemporal organization of mitotic events in mechanically perturbed C. elegans embryos.Biophysical journal · 2025Article
- The mechanobiology of biomolecular condensates.Biophysics reviews · 2025Review
- Axisymmetric thermoviscous and thermal expansion flows for microfluidics.Journal of engineering mathematics · 2025Article
- Three-dimensional optofluidic control using reconfigurable thermal barriers.Nature photonics · 2025Article
- Heat application in live cell imaging.FEBS open bio · 2024Review
- Optical characterization of molecular interaction strength in protein condensates.Molecular biology of the cell · 2024Article
- Quantitative perturbation-phenotype maps reveal nonlinear responses underlying robustness of PAR-dependent asymmetric cell division.PLoS biology · 2024Article
- Optical characterization of molecular interaction strength in protein condensates.bioRxiv : the preprint server for biology · 2024Article
8 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent advances in cell biology enable precise molecular perturbations. The spatiotemporal organization of cells and organisms, however, also depends on physical processes such as diffusion or cytoplasmic flows, and strategies to perturb physical transport inside cells are not yet available. Here, we demonstrate focused-light-induced cytoplasmic streaming (FLUCS). FLUCS is local, directional, dynamic, probe-free, physiological, and is even applicable through rigid egg shells or cell walls. We explain FLUCS via time-dependent modelling of thermoviscous flows. Using FLUCS, we demonstrate that cytoplasmic flows drive partitioning-defective protein (PAR) polarization in Caenorhabditis elegans zygotes, and that cortical flows are sufficient to transport PAR domains and invert PAR polarity. In addition, we find that asymmetric cell division is a binary decision based on gradually varying PAR polarization states. Furthermore, the use of FLUCS for active microrheology revealed a metabolically induced fluid-to-solid transition of the yeast cytoplasm. Our findings establish how a wide range of transport-dependent models of cellular organization become testable by FLUCS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.