ArticleNature neuroscience2018
Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals.
Article in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05020626 (Modelling Tau Deposition and Distribution From Diffusion Tensor Imaging With Generative Adversarial Network for Alzheimer's Disease Diagnosis), which is not on this map. Cited by 174 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Modelling Tau Deposition and Distribution From Diffusion Tensor Imaging With Generative Adversarial Network for Alzheimer's Disease Diagnosis
Who cites it
174 citing papers in PubMed, 273 citations in OpenAlex.
- Developing an SNR-efficient tensor-valued diffusion encoding protocol for studying brain microstructural changes in neurodegeneration.medRxiv : the preprint server for health sciences · 2026Article
- Structural and molecular determinants of medial temporal lobe network vulnerability in aging and Alzheimer's disease.Alzheimer's research & therapy · 2026Article
- Hierarchical organization of tau topography across the Alzheimer's disease continuum integrates amyloid, connectome, and intrinsic molecular vulnerability.Communications biology · 2026Article
- Differential associations of plasma biomarkers with Alzheimer's disease and small vessel disease: A multimodal imaging study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Diffusion-relaxation MRI as virtual histology: separable microstructural signatures of AD pathology in ex vivo human brain.Research square · 2026Article
- Separable multidimensional MRI signatures of cellular and structural pathology in Alzheimer's disease.bioRxiv : the preprint server for biology · 2026Article
- Elevation in network dynamics amplifies amyloid-dependent tau pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- α-synuclein positivity is associated with decline in brain microstructure in the Alzheimer's disease spectrum.Alzheimer's research & therapy · 2026Article
- Progression of fiber bundle damage in amnestic Alzheimer's disease and LATE: a 2-year fixel-based study.GeroScience · 2026Article
- APOE-mediated sex differences in microvascular pathology and AD-associated proteinopathies in the medial temporal lobe.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Functional connectivity patterns of the cerebellar components of intrinsic connectivity networks in clinically diagnosed probable Alzheimer's disease.BMC medical imaging · 2026Article
- Structural changes in gray matter and white matter across the Alzheimer's disease continuum.Frontiers in neuroscience · 2026Article
- Living Alone, Early Tau Pathology, and Loneliness in Cognitively Unimpaired Older Adults During the COVID-19 Pandemic.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026Article
- Disrupted Brain Hierarchical Organization in Alzheimer's Disease Progression.medRxiv : the preprint server for health sciences · 2025Article
- Longitudinal biomarker studies in human neuroimaging: capturing biological change of Alzheimer's pathology.Alzheimer's research & therapy · 2025Review
- Association Between U-p53AZ Blood Biomarker and White Matter Microstructure in Early Alzheimer's Disease: A Cross-Sectional Study Using AlzoSure® Predict.Health science reports · 2025Article
- Locus coeruleus-entorhinal cortex tract integrity is linked to plasma tau and glial fibrillary acidic protein.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Patient-specific functional brain architecture explains cortical patterns of tau PET in Alzheimer's disease.bioRxiv : the preprint server for biology · 2025Article
- White matter microstructure is differentially impacted by cerebral amyloid angiopathy, neurofibrillary tangles, and neuritic plaque co-pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Autophagic impairment in sleep-wake circuitry is linked to sleep loss at the early stages of Alzheimer's disease.Molecular neurodegeneration · 2025Article
114 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Animal models of Alzheimer's disease have suggested that tau pathology propagation, facilitated by amyloid pathology, may occur along connected pathways. To investigate these ideas in humans, we combined amyloid scans with longitudinal data on white matter connectivity, hippocampal volume, tau positron emission tomography and memory performance in 256 cognitively healthy older individuals. Lower baseline hippocampal volume was associated with increased mean diffusivity of the connecting hippocampal cingulum bundle (HCB). HCB diffusivity predicted tau accumulation in the downstream-connected posterior cingulate cortex in amyloid-positive but not in amyloid-negative individuals. Furthermore, HCB diffusivity predicted memory decline in amyloid-positive individuals with high posterior cingulate cortex tau binding. Our results provide in vivo evidence that higher amyloid pathology strengthens the association between HCB diffusivity and tau accumulation in the downstream posterior cingulate cortex and facilitates memory decline. This confirms amyloid's crucial role in potentiating neural vulnerability and memory decline marking the onset of preclinical Alzheimer's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.