ArticleNature genetics2018
CLCN2 chloride channel mutations in familial hyperaldosteronism type II.
Abstract readLetter
In one paragraph
Article in Nature genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 2 pooled it
20.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
123 citing papers in PubMed, 2 syntheses or guidelines pooled it, 258 citations in OpenAlex.
- Differences in the clinical and hormonal presentation of patients with familial and sporadic primary aldosteronism.Frontiers in endocrinology · 2024Pooled it
- Identification of risk loci for primary aldosteronism in genome-wide association studies.Nature communications · 2022Pooled it
- [Nature medicine · 2023Trial
- Identification of Susceptibility Genes for Hypertension in the Dong Ethnic Population of Tongdao.Biochemical genetics · 2026Article
- Primary aldosteronism.Nature reviews. Disease primers · 2026Review
- ClC-2 Contributes to Hypotonicity-Induced Adrenal Aldosterone Secretion.Acta physiologica (Oxford, England) · 2026Article
- Adrenal histologic and genetic characteristics of primary aldosteronism in late adulthood.European journal of endocrinology · 2026Article
- The genetics of hypertension.Nature reviews. Nephrology · 2026Review
- Emerging methods for subtype differentiation in primary aldosteronism.Journal of internal medicine · 2026Review
- Regulation of Aldosterone Secretion by Substance P and the Neurokinin Type 1 Receptor in Aldosterone-Producing Adenomas.Journal of the American Heart Association · 2026Article
- Targeting astrocytic CLC2(CLCN2) restores myelin regeneration through inhibition of SPP1/CD44 signaling pathway in leukoencephalopathy.Molecular psychiatry · 2026Article
- Identification of a novelFrontiers in genetics · 2026Article
- Comparative Proteomic Profiling of Adrenocortical Neoplasia Using Mass Spectrometry.Journal of proteome research · 2025Article
- Molecular investigation of primary aldosteronism: exploring genetic heterogeneity in understudied populations.Archives of endocrinology and metabolism · 2025Article
- Osmolarity Controls Oscillatory Calcium Signaling to Reduce Autonomous Aldosterone Production in Zona Glomerulosa Cells.Endocrinology · 2025Article
- Adrenal causes of endocrine hypertension in childhood or adolescence.Journal of endocrinological investigation · 2025Review
- Gene regulatory activity associated with polycystic ovary syndrome revealed DENND1A-dependent testosterone production.Nature communications · 2025Article
- Regulation of testosterone synthesis in Leydig cells by ClC-2 chloride channel.Reproduction (Cambridge, England) · 2025Article
- Pleiotropic Effects of the NSAID Fenamates on Chloride Channels: Opportunity for Ion Channelopathies?Pharmacology research & perspectives · 2025Review
- Genetic Testing for Primary Aldosteronism in SPAIN: Results From the SPAIN-ALDO Registry and Review of the Literature.The Journal of clinical endocrinology and metabolism · 2025Review
63 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
29 authors at 15 institutions in 4 countries.
Ute I SchollDepartment of Nephrology, Medical School, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. ute.scholl@charite.de.ORCID http://orcid.org/0000-0002-0309-8045
Gabriel Stölting *Institute of Complex Systems, Zelluläre Biophysik (ICS-4), Forschungszentrum Jülich, Jülich, Germany.ORCID http://orcid.org/0000-0002-2339-0545
Julia Schewe *Department of Nephrology, Medical School, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Anne ThielDepartment of Nephrology, Medical School, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID http://orcid.org/0000-0002-9523-2351
Hua TanInstitute of Complex Systems, Zelluläre Biophysik (ICS-4), Forschungszentrum Jülich, Jülich, Germany.
Carol Nelson-WilliamsDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-0768-4751
Alfred A VichotDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.
Sheng Chih JinDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.
Erin LoringDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.
Verena UntietInstitute of Complex Systems, Zelluläre Biophysik (ICS-4), Forschungszentrum Jülich, Jülich, Germany.ORCID http://orcid.org/0000-0002-1888-6378
Taekyeong YooDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
Jungmin ChoiDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.
Shengxin XuEndocrine Hypertension Research Center, University of Queensland Diamantina Institute, Greenslopes and Princess Alexandra Hospitals, Brisbane, Queensland, Australia.
Aihua WuEndocrine Hypertension Research Center, University of Queensland Diamantina Institute, Greenslopes and Princess Alexandra Hospitals, Brisbane, Queensland, Australia.
Marieluise KirchnerProteomics Platform, Max Delbrück Center for Molecular Medicine in the Helmholtz Society and Core Unit of Proteomics, Berlin Institute of Health, Berlin, Germany.
Philipp MertinsProteomics Platform, Max Delbrück Center for Molecular Medicine in the Helmholtz Society and Core Unit of Proteomics, Berlin Institute of Health, Berlin, Germany.
Lars C RumpDepartment of Nephrology, Medical School, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Ali Mirza OnderNephrology, Le Bonheur Children's Hospital, Memphis, TN, USA.
Cory GambleCooper Clinic, PA, Fort Smith, AR, USA.
Daniel McKenneyPeyton Manning Children's Hospital at St. Vincent, Indianapolis, IN, USA.
Robert W LashDivision of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, MI, USA.
Deborah P JonesDivision of Nephrology and Hypertension, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA.
Gary ChuneOlin Teague Veterans Administration Hospital, Temple, TX, USA.
Priscila GagliardiDivision of Endocrinology, Nemours Children's Specialty Care, Jacksonville, FL, USA.
Murim ChoiDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0002-9195-1455
Richard GordonEndocrine Hypertension Research Center, University of Queensland Diamantina Institute, Greenslopes and Princess Alexandra Hospitals, Brisbane, Queensland, Australia.
Michael StowasserEndocrine Hypertension Research Center, University of Queensland Diamantina Institute, Greenslopes and Princess Alexandra Hospitals, Brisbane, Queensland, Australia.
Christoph FahlkeInstitute of Complex Systems, Zelluläre Biophysik (ICS-4), Forschungszentrum Jülich, Jülich, Germany.
Richard P LiftonDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.
Howard Hughes Medical Institute · USForschungszentrum Jülich · DEThe University of Queensland · AUHeinrich Heine University Düsseldorf · DEMax Delbrück Center · DESeoul National University · KRBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DECooper Clinic · USLe Bonheur Children's Hospital · USNemours Children’s Clinic · USOlin E. Teague Veterans Medical Center · USPeyton Manning Children’s Hospital at St.Vincent · USUniversity of Michigan · USVanderbilt University · USYale University · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MThe Regulation of Renal Epithelial Cell Junction Assembly and PolarizationP01DK017433 · NIDDK · YALE UNIVERSITY · PI FORBUSH, BLISS · 1986 to 2018
$29.5MRenal Physiology and Phenotyping CoreP30DK079310 · NIDDK · YALE UNIVERSITY · PI ARONSON, PETER S. · 2008 to 2022
$16.8MYale Center for Mendelian GenomicsUM1HG006504 · NHGRI · YALE UNIVERSITY · PI GERSTEIN, MARK BENDER, GUNEL, MURAT · 2016 to 2020
$14.8MYale Center for Mendelian DisordersU54HG006504 · NHGRI · YALE UNIVERSITY · PI GERSTEIN, MARK BENDER, GUNEL, MURAT · 2012 to 2015
$11.0MPATHOPHYSIOLOGY OF ACUTE AND CHRONIC RENAL DISEASET32DK007276 · NIDDK · YALE UNIVERSITY · PI ARONSON, PETER S., CANTLEY, LLOYD G · 1986 to 2022
$9.3MHigh Performance Computing Instrumentation for the Yale Center for Genome AnalysiS10OD018521 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2015 to 2015
$890kNCATS NIH HHS UL1 TR001863NHGRI NIH HHS U54 HG006504NHGRI NIH HHS UM1 HG006504NIDDK NIH HHS P01 DK017433NIDDK NIH HHS P30 DK079310NIDDK NIH HHS T32 DK007276NIH HHS S10 OD018521
Abstract
Primary aldosteronism, a common cause of severe hypertension
Indexed as
MutationAdolescentAdrenal GlandsAdultAmino Acid SequenceChildChloride ChannelsCLC-2 Chloride ChannelsCohort StudiesDNA Mutational AnalysisFemaleHumansHyperaldosteronismInfantMalePedigreeChloride ChannelsCLC-2 Chloride Channels
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.