ArticleNature communications2018
A NIN-LIKE PROTEIN mediates nitrate-induced control of root nodule symbiosis in Lotus japonicus.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed, 189 citations in OpenAlex.
- Nonnodulating Fagales retain the functional NODULE INCEPTION gene.The New phytologist · 2026Article
- Nitrogen-Controlled Host Gatekeeping: Regulatory Chokepoints Across Four Windows for Diazotroph Access.International journal of molecular sciences · 2026Article
- The root nodule symbiosis regulator NIN exhibits broad DNA binding specificity conferred by an NLP-inherited motif.Science advances · 2026Article
- Nitrate-induced NLP1 SUMOylation regulates nitrate signaling and root nodulation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Phosphate deficiency reduces nodule formation through a phosphate starvation response-like protein in Phaseolus vulgaris.Plant & cell physiology · 2025Article
- Single-Cell Omics in Legumes: Research Trends and Applications.Plants (Basel, Switzerland) · 2025Review
- Improved rapid and efficient hairy root transformation usingPlant biotechnology (Tokyo, Japan) · 2025Article
- Time lags in the regulation of symbiotic nitrogen fixation.The New phytologist · 2025Article
- Symbiotic nitrogen fixation: a launchpad for investigating old and new challenges.Journal of experimental botany · 2025Article
- Peptide hormones in plants.Molecular horticulture · 2025Review
- Understanding the Crucial Role of Phosphate and Iron Availability in Regulating Root Nodule Symbiosis.Plant & cell physiology · 2024Review
- GmbZIP4a/b Positively Regulate Nodule Number by Affecting Cytokinin Biosynthesis inInternational journal of molecular sciences · 2024Article
- Conserved cis-elements enable NODULES WITH ACTIVATED DEFENSE1 regulation by NODULE INCEPTION during nodulation.The Plant cell · 2024Article
- Host-imposed control mechanisms in legume-rhizobia symbiosis.Nature microbiology · 2024Review
- Article
- NIN-like proteins (NLPs) as crucial nitrate sensors: an overview of their roles in nitrogen signaling, symbiosis, abiotic stress, and beyond.Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Review
- Staying hungry: a roadmap to harnessing central regulators of symbiotic nitrogen fixation under fluctuating nitrogen availability.aBIOTECH · 2024Article
- CLAVATA signaling in plant-environment interactions.Plant physiology · 2024Review
- Dynamics of hemoglobins during nodule development, nitrate response, and dark stress in Lotus japonicus.Journal of experimental botany · 2024Article
- IMA peptides regulate root nodulation and nitrogen homeostasis by providing iron according to internal nitrogen status.Nature communications · 2024Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Legumes and rhizobia establish symbiosis in root nodules. To balance the gains and costs associated with the symbiosis, plants have developed two strategies for adapting to nitrogen availability in the soil: plants can regulate nodule number and/or stop the development or function of nodules. Although the former is accounted for by autoregulation of nodulation, a form of systemic long-range signaling, the latter strategy remains largely enigmatic. Here, we show that the Lotus japonicus NITRATE UNRESPONSIVE SYMBIOSIS 1 (NRSYM1) gene encoding a NIN-LIKE PROTEIN transcription factor acts as a key regulator in the nitrate-induced pleiotropic control of root nodule symbiosis. NRSYM1 accumulates in the nucleus in response to nitrate and directly regulates the production of CLE-RS2, a root-derived mobile peptide that acts as a negative regulator of nodule number. Our data provide the genetic basis for how plants respond to the nitrogen environment and control symbiosis to achieve proper plant growth.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.