Evidence map›Paper›PMID 29402963›Full record

ArticleScientific reports2018

Fast assessment of lipid content in arteries in vivo by intravascular photoacoustic tomography.

Yingchun Cao, Ayeeshik Kole, Jie Hui, Yi Zhang, Jieying Mai, Mouhamad Alloosh, Michael Sturek, Ji-Xin Cheng

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yingchun CaoWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, 47907, USA.
Ayeeshik KoleWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, 47907, USA.
Jie HuiDepartment of Physics and Astronomy, Purdue University, West Lafayette, Indiana, 47907, USA.ORCID http://orcid.org/0000-0001-9981-727X
Yi ZhangDepartment of Physics, Boston University, Boston, Massachusetts, 02215, USA.
Jieying MaiWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, 47907, USA.
Mouhamad AllooshDepartment of Cellular & Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana, 46202, USA.
Michael SturekWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, 47907, USA.
Ji-Xin ChengWeldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, 47907, USA. jxcheng@bu.edu.
Purdue University West Lafayette · USBoston University · USIndiana University School of Medicine

Funding

Translation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Tamara S Hannon · 2015 to 2026
$17.4M
Indiana Medical Scientist/Engineer Training ProgramT32GM077229 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN, HERBERT, BRITTNEY-SHEA · 2008 to 2022
$6.0M
Sensing Vulnerable Plaque in vivo by an All-optical Intravascular Ultrasound and Photoacoustic CatheterR01HL125385 · NHLBI · PURDUE UNIVERSITY · PI CHENG, JI-XIN · 2015 to 2023
$4.6M
NHLBI NIH HHS R01 HL125385NIDDK NIH HHS P30 DK097512NIGMS NIH HHS T32 GM077229
6 · The paper itself

Abstract

Intravascular photoacoustic tomography is an emerging technology for mapping lipid deposition within an arterial wall for the investigation of the vulnerability of atherosclerotic plaques to rupture. By converting localized laser absorption in lipid-rich biological tissue into ultrasonic waves through thermoelastic expansion, intravascular photoacoustic tomography is uniquely capable of imaging the entire arterial wall with chemical selectivity and depth resolution. However, technical challenges, including an imaging catheter with sufficient sensitivity and depth and a functional sheath material without significant signal attenuation and artifact generation for both photoacoustics and ultrasound, have prevented in vivo application of intravascular photoacoustic imaging for clinical translation. Here, we present a highly sensitive quasi-collinear dual-mode photoacoustic/ultrasound catheter with elaborately selected sheath material, and demonstrated the performance of our intravascular photoacoustic tomography system by in vivo imaging of lipid distribution in rabbit aortas under clinically relevant conditions at imaging speeds up to 16 frames per second. Ex vivo evaluation of fresh human coronary arteries further confirmed the performance of our imaging system for accurate lipid localization and quantification of the entire arterial wall, indicating its clinical significance and translational capability.

Indexed as

AdultAnimalsAortaAtherosclerosisBiocompatible MaterialsCathetersCoronary VesselsFemaleHumansImage Processing, Computer-AssistedLipidsMalePhotoacoustic TechniquesPlaque, AtheroscleroticPolyurethanesRabbitsBiocompatible MaterialsLipidsPolyurethanes

Identifiers

PMID29402963
PMCPMC5799328
OpenAlexW2805628886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.