ArticleScientific reports2018
Spatiotemporal organization of cilia drives multiscale mucus swirls in model human bronchial epithelium.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Quantitative analysis of mucociliary activity by computational high-speed video reflection microscopy.European biophysics journal : EBJ · 2026Article
- Modeling tissue-scale ciliary transport and mixing in three-dimensional Newtonian flow.PLoS computational biology · 2025Article
- Serum valeric acid stimulates lung epithelial cilia assembly and improves prognosis in patients with severe respiratory infections.Frontiers in pharmacology · 2025Article
- Revolutionizing Epithelial Differentiability Analysis in Small Airway-on-a-Chip Models Using Label-Free Imaging and Computational Techniques.Biosensors · 2024Article
- Live imaging of airway epithelium reveals that mucociliary clearance modulates SARS-CoV-2 spread.Nature communications · 2024Article
- High-throughput Bronchus-on-a-Chip system for modeling the human bronchus.Scientific reports · 2024Article
- Surface Cross-Linking by Macromolecular Tethers Enhances Virus-like Particles' Resilience to Mucosal Stress Factors.ACS nano · 2024Article
- MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium.Science advances · 2022Article
- Review
- Fluid Mechanics of Mosaic Ciliated Tissues.Physical review letters · 2021Article
- Article
- Mucus, Microbiomes and Pulmonary Disease.Biomedicines · 2021Review
- Rheological analysis of sputum from patients with chronic bronchial diseases.Scientific reports · 2020Article
- Multiscale mechanics of mucociliary clearance in the lung.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Strategies for measuring airway mucus and mucins.Respiratory research · 2019Review
- Male reproductive tract cilia beat to a different drummer.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Assembly, Release, and Transport of Airway Mucins in Pigs and Humans.Annals of the American Thoracic Society · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mucociliary clearance is a biomechanical mechanism of airway protection. It consists of the active transport along the bronchial tree of the mucus, a fluid propelled by the coordinated beating of a myriad of cilia on the epithelial surface of the respiratory tract. The physics of mucus transport is poorly understood because it involves complex phenomena such as long-range hydrodynamic interactions, active collective ciliary motion, and the complex rheology of mucus. We propose a quantitative physical analysis of the ciliary activity and mucus transport on a large panel of human bronchial cultures from control subjects, patients with asthma and chronic obstructive pulmonary disease obtained from endobronchial biopsies. Here we report on the existence of multiple ciliary domains with sizes ranging from the tens of a micron to the centimeter, where ciliary beats present a circular orientational order. These domains are associated with circular mucus flow patterns, whose size scales with the average cilia density. In these domains, we find that the radial increase of the ciliated cell density coupled with the increase in the orientational order of ciliary beats result in a net local force proportional to the mucus velocity. We propose a phenomenological physical model that supports our results.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.