ArticleBioorganic & medicinal chemistry letters2018
Potentiation of the activity of β-lactam antibiotics by farnesol and its derivatives.
Article in Bioorganic & medicinal chemistry letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Research Progress on the Quorum Sensing System ofPathogens (Basel, Switzerland) · 2026Review
- Effect of Quorum Sensing Molecule Farnesol on Mixed Biofilms ofAntibiotics (Basel, Switzerland) · 2023Article
- β-Lactam potentiators to re-sensitize resistant pathogens: Discovery, development, clinical use and the way forward.Frontiers in microbiology · 2022Review
- Lipid Nanoparticles Loaded with Farnesol or Geraniol to Enhance the Susceptibility ofPharmaceutics · 2021Article
- β-Lactams against the Fortress of the Gram-PositiveChemical reviews · 2021Review
- Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect againstJournal of fungi (Basel, Switzerland) · 2020Review
- The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections.Antibiotics (Basel, Switzerland) · 2020Review
- Re-sensitizing Ampicillin and Kanamycin-ResistantFrontiers in bioengineering and biotechnology · 2020Article
- Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases.BioMed research international · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Farnesol, a sesquiterpene alcohol, potentiates the activity of β-lactam antibiotics against antibiotic-resistant bacteria. We document that farnesol and two synthetic derivatives (compounds 2 and 6) have poor antibacterial activities of their own, but they potentiate the activities of ampicillin and oxacillin against Staphylococcus aureus strains (including methicillin-resistant S. aureus). These compounds attenuate the rate of growth of bacteria, which has to be taken into account in assessment of the potentiation effect.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.