ArticleInternational journal of hygiene and environmental health2018
Prenatal organophosphate insecticide exposure and infant sensory function.
Article in International journal of hygiene and environmental health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Pediatric hearing loss in the universal newborn hearing screening era: etiologies, risk indicators, and clinical phenotypes.Frontiers in public health · 2026Review
- Profiling the cytotoxic effects of naled and other pesticides in primary human placental cytotrophoblasts.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Gestational Chlorpyrifos Exposure Imparts Lasting Alterations to the Rat Somatosensory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The Study of Environmental Exposure of Mothers and Infants Impacted by Large-Scale Agriculture (SEMILLA): Description of the Aims and Methods of a Community-Based Birth Cohort Study.Children (Basel, Switzerland) · 2024Article
- An exposome atlas of serum reveals the risk of chronic diseases in the Chinese population.Nature communications · 2024Article
- Prenatal fluoride exposure, offspring visual acuity and autonomic nervous system function in 6-month-old infants.Environment international · 2024Article
- Literature landscape of neurodevelopment and pesticides: A scoping review of methodologies.Global epidemiology · 2023Article
- Retinol and Pro-Vitamin A Carotenoid Nutritional Status during Pregnancy Is Associated with Newborn Hearing Screen Results.Nutrients · 2023Article
- Cognitive Impairment and Neurodegenerative Diseases Development Associated with Organophosphate Pesticides Exposure: a Review Study.Neurotoxicity research · 2022Review
- Neuronal differentiation pathways and compound-induced developmental neurotoxicity in the human neural progenitor cell test (hNPT) revealed by RNA-seq.Chemosphere · 2022Article
- Exploring the effects and mechanisms of organophosphorus pesticide exposure and hearing loss.Frontiers in public health · 2022Review
- Review of the environmental prenatal exposome and its relationship to maternal and fetal health.Reproductive toxicology (Elmsford, N.Y.) · 2020Review
- Prenatal exposure to legacy contaminants and visual acuity in Canadian infants: a maternal-infant research on environmental chemicals study (MIREC-ID).Environmental health : a global access science source · 2020Article
- Prenatal exposure to the herbicide 2,4-D is associated with deficits in auditory processing during infancy.Environmental research · 2019Article
- A pilot study of maternal exposure to organophosphate pesticides and newborn neurodevelopment in Thailand.International journal of occupational and environmental health · 2017Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundOccupational studies suggest that exposure to organophosphate insecticides (OPs) can lead to vision or hearing loss. Yet the effects of early-life exposure on visual and auditory function are unknown. Here we examined associations between prenatal OP exposure and grating visual acuity (VA) and auditory brainstem response (ABR) during infancy.
methods30 OPs were measured in umbilical cord blood using gas chromatography tandem mass spectrometry in a cohort of Chinese infants. Grating visual acuity (VA) (n = 179-200) and auditory brainstem response (ABR) (n = 139-183) were assessed at 6 weeks, 9 months, and 18 months. Outcomes included VA score, ABR wave V latency and central conduction time, and head circumference (HC). Associations between sensory outcomes during infancy and cord OPs were examined using linear mixed models.
resultsPrenatal chlorpyrifos exposure was associated with lower 9-month grating VA scores; scores were 0.64 (95% CI: -1.22, -0.06) points lower for exposed versus unexposed infants (p = 0.03). The OPs examined were not associated with infant ABR latencies, but chlorpyrifos and phorate were both significantly inversely associated with HC at 9 months; HCs were 0.41 (95% CI: 0.75, 0.6) cm and 0.44 (95% CI: 0.88, 0.1) cm smaller for chlorpyrifos (p = 0.02) and phorate (p = 0.04), respectively.
conclusionsWe found deficits in grating VA and HC in 9-month-old infants with prenatal exposure to chlorpyrifos. The clinical significance of these small but statistically significant deficits is unclear. However, the disruption of visual or auditory pathway maturation in infancy could potentially negatively affect downstream cognitive development.
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