ArticleeLife2018
The last common ancestor of animals lacked the HIF pathway and respired in low-oxygen environments.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 122 citations in OpenAlex.
- Hypoxia-induced gene expression changes in N. vectensis embryos.Scientific reports · 2026Article
- Transcriptomic Adjustment to Decreasing Oxygen Reveals Novel Functional Strategies for Extreme Hypoxia Tolerance in the Copepod Tigriopus californicus.Genome biology and evolution · 2026Article
- Hypoxia, ROS, and HIF Signaling in I/R Injury: Implications and Future Prospects.Antioxidants (Basel, Switzerland) · 2026Review
- Oxygen regulation in the earliest animals: spatiotemporal resolution of oxygen dynamics in single-osculumFrontiers in physiology · 2026Article
- Linker Length and Composition within Disordered Binding Motifs Modulates the Avidity and Reversibility of a Multivalent Protein Interaction Switch.Journal of molecular biology · 2025Article
- Relating differential gene expression and genomic analyses to functional adaptation at various developmental stages of the blue crab, Callinectes sapidus.BMC genomics · 2025Article
- ERFVIIs as transducers of oxygen-sensing in the evolution of land plant response to hypoxia.Molecular plant · 2025Article
- Benthic diel oxygen variability and stress as potential drivers for animal diversification in the Neoproterozoic-Palaeozoic.Nature communications · 2025Article
- A reassessment of the "hard-steps" model for the evolution of intelligent life.Science advances · 2025Review
- Systematic and comprehensive insights into HIF-1 stabilization under normoxic conditions: implications for cellular adaptation and therapeutic strategies in cancer.Cellular & molecular biology letters · 2025Review
- Did mitophagy follow the origin of mitochondria?Autophagy · 2024Review
- Targeting hypoxia-inducible factors: therapeutic opportunities and challenges.Nature reviews. Drug discovery · 2024Review
- The genomes of the aquarium spongesF1000Research · 2024Article
- Respiration kinetics and allometric scaling in the demosponge Halichondria panicea.BMC ecology and evolution · 2023Article
- Myxozoans (Cnidaria) do not Retain Key Oxygen-Sensing and Homeostasis Toolkit Genes.Genome biology and evolution · 2023Article
- Exploring genome gene content and morphological analysis to test recalcitrant nodes in the animal phylogeny.PloS one · 2023Article
- The evolutionarily conserved arginyltransferase 1 mediates a pVHL-independent oxygen-sensing pathway in mammalian cells.Developmental cell · 2022Article
- Time Domains of Hypoxia Responses and -Omics Insights.Frontiers in physiology · 2022Review
- The origin and distribution of the main oxygen sensing mechanism across metazoans.Frontiers in physiology · 2022Article
- A chromosome-scale genome assembly and karyotype of the ctenophore Hormiphora californensis.G3 (Bethesda, Md.) · 2021Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Animals have a carefully orchestrated relationship with oxygen. When exposed to low environmental oxygen concentrations, and during periods of increased energy expenditure, animals maintain cellular oxygen homeostasis by enhancing internal oxygen delivery, and by enabling the anaerobic production of ATP. These low-oxygen responses are thought to be controlled universally across animals by the hypoxia-inducible factor (HIF). We find, however, that sponge and ctenophore genomes lack key components of the HIF pathway. Since sponges and ctenophores are likely sister to all remaining animal phyla, the last common ancestor of extant animals likely lacked the HIF pathway as well. Laboratory experiments show that the marine sponge
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.