ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2018
Updated Review of Fish Analgesia.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Advancing Zebrafish (Veterinary sciences · 2025Review
- Pharmacokinetics, bioavailability and plasma protein binding of tolfenamic acid in rainbow trout (Oncorhynchus mykiss).Veterinary medicine and science · 2024Article
- Antinociceptive Analysis of Natural Monoterpenes Eugenol, Menthol, Carvacrol and Thymol in a Zebrafish Larval Model.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Alfaxalone does not have long-term effects on goldfish pyramidal neuron action potential properties or GABAFEBS open bio · 2024Article
- Evaluation of Candidates for Systemic Analgesia and General Anesthesia in the Emerging Model Cephalopod,Biology · 2023Article
- Ketoprofen as an emerging contaminant: occurrence, ecotoxicity and (bio)removal.Frontiers in microbiology · 2023Review
- Estimating Discard Mortality in Commercial Fisheries without Fish Dying: A 3R Challenge.Animals : an open access journal from MDPI · 2022Article
- Pharmacokinetic Studies in Elasmobranchs: Meloxicam Administered at 0.5 mg/kg Using Intravenous, Intramuscular, and Oral Routes to Nusehound Sharks (Frontiers in veterinary science · 2022Article
- Gular Cutaneous Fibrosarcoma and Anatomophysiological Considerations for Anaesthesia in a Saddled Bichir,Case reports in veterinary medicine · 2022Article
- Pharmacokinetics and Bioavailability of Carprofen in Rainbow Trout (Pharmaceutics · 2021Article
- Identification of Individual Zebrafish (Animals : an open access journal from MDPI · 2021Article
- Current Methods to Investigate Nociception and Pain in Zebrafish.Frontiers in neuroscience · 2021Review
- Pharmacokinetics of Ketoprofen in Nile Tilapia (Frontiers in veterinary science · 2020Article
- Mapping of Morphine-InducedFrontiers in neuroanatomy · 2020Article
- "But It's Just a Fish": Understanding the Challenges of Applying the 3Rs in Laboratory Aquariums in the UK.Animals : an open access journal from MDPI · 2019Article
- Review
- Intramuscular infiltration of a local anesthetic, lidocaine, does not result in adverse behavioural side effects in rainbow trout.Scientific reports · 2018Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Analgesics are an integral part of routine pain management in mammals, yet their use in fish is still limited. Some recommendations on the use of analgesics in fish are currently in the literature; however, information on the properties of analgesic drugs in most fish species is still scarce and sometimes misleading. The present review of information on the use of analgesics in fish was thus compiled to help clinicians make an informed decision as to which drug and dose to use. The main agents that have been investigated are opioids, NSAID, and local anesthetics, primarily in rainbow trout and zebrafish. There is presently no overwhelming evidence of efficacy for most analgesics in fish, although beneficial effects on behavior and physiologic parameters have been reported in many instances, especially associated with morphine administration. Furthermore, most analgesics did not result in significant adverse side effects. Thus, analgesics could be administered whenever it is considered that an animal might experience pain, given that the drugs appear not to cause harm and may be beneficial. However, caution must be advised because 1) important interspecies variation has been reported and 2) unforeseen effects could affect experimental results. Further research is needed to investigate analgesic use in fish. This should be accompanied by research aimed at improving our knowledge of the various species of fish. The current lack of a validated approach to assessing pain in fish limits our ability to evaluate the efficacy of analgesics in fish.
Indexed as
Identifiers
29402345PMC5875091W2909780196What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.