Evidence map›Paper›PMID 29402317›Full record

Observational studyBMC research notes2018

Predictors of therapy failure in newly diagnosed pulmonary tuberculosis cases in Beira, Mozambique.

Damiano Pizzol, Nicola Veronese, Claudia Marotta, Francesco Di Gennaro, Jorge Moiane, Kajal Chhaganlal, Laura Monno, Giovanni Putoto, Walter Mazzucco, Annalisa Saracino

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in BMC research notes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Tuberculosis Treatment Outcome and Predictors in Africa: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021
    Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Damiano PizzolResearch Unit, Doctors with Africa-CUAMM, Beira, Mozambique.
Nicola VeroneseDepartment of Medicine (DIMED)-Geriatrics Section, University of Padova, Padua, Italy.
Claudia MarottaDepartment of Science for Health Promotion and Mother to Child Care "G. D'Alessandro", University of Palermo, via del Vespro, 133, Palermo, Italy.
Francesco Di GennaroDepartment of Infectious Diseases, University of Bari "Aldo Moro", P.zza G Cesare 3, Bari, Italy. cicciodigennaro@yahoo.it.
Jorge MoianeFaculty of Health Sciences, Catholic University of Mozambique, Center for Research in Infectious Diseases, Beira, Mozambique.
Kajal ChhaganlalFaculty of Health Sciences, Catholic University of Mozambique, Center for Research in Infectious Diseases, Beira, Mozambique.
Laura MonnoDepartment of Infectious Diseases, University of Bari "Aldo Moro", P.zza G Cesare 3, Bari, Italy.
Giovanni PutotoResearch Section, Doctors with Africa CUAMM, Padua, Italy.
Walter MazzuccoDepartment of Science for Health Promotion and Mother to Child Care "G. D'Alessandro", University of Palermo, via del Vespro, 133, Palermo, Italy.
Annalisa SaracinoDepartment of Infectious Diseases, University of Bari "Aldo Moro", P.zza G Cesare 3, Bari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTuberculosis (TB) remains a major global health issue, ranking in the top ten causes of death worldwide. A deep understanding of factors influencing poor treatment outcomes may allow the development of additional treatment strategies, focused on the most vulnerable groups. Aims of the study were: (i) to evaluate the treatment outcome among TB subjects followed in an outpatient setting and (ii) to analyze factors associated with treatment failure in newly diagnosed patients with pulmonary TB in Beira, the second largest city of Mozambique.

resultsA total of 301 TB adult patients (32.6% females) were enrolled. Among them, 62 (20.6%) experienced a treatment failure over a 6 months follow-up. On multivariate model, being males (O.R. = 1.73; 95% CI 1.28-2.15), absence of education (O.R. = 1.85; 95% CI 1.02-2.95), monthly income under 50 dollars (O.R. = 1.74; 95% CI 1.24-2.21) and being employed (O.R. = 1.57; 95% CI 1.21-1.70), low body mass index values (O.R. = 1.42; 95% CI 1.18-1.72) and HIV status (O.R. = 1.42; 95% CI 1.10-1.78) increased the likelihood of therapy failure over 6 months of follow-up. In this study, patients who need more medical attention were young males, malnourished, with low income and low educational degree and HIV positive. These subjects were more likely to fail therapy.

Indexed as

AdolescentAdultAntitubercular AgentsBody Mass IndexCoinfectionEducational StatusEmploymentFemaleHIV InfectionsHumansMaleMalnutritionMozambiqueOdds RatioOutpatientsPovertyAntitubercular AgentsMozambiqueTherapy failureTuberculosis

Identifiers

PMID29402317
PMCPMC5800087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.