ArticleCardiovascular diabetology2018
Increase in relative skeletal muscle mass over time and its inverse association with metabolic syndrome development: a 7-year retrospective cohort study.
Article in Cardiovascular diabetology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of muscle wasting with mortality risk among adults: A systematic review and meta-analysis of prospective studies.Journal of cachexia, sarcopenia and muscle · 2023Pooled it
- Visceral adiposity is associated with low trabecular bone score in postmenopausal women with osteopenia.Skeletal radiology · 2026Article
- Frailty and Cardiovascular Events as Determined by Body Composition: A Systematic Review.Chronic diseases and translational medicine · 2026Review
- Association between skeletal muscle index and kidney stones in health screening populations: a single-center cross-sectional study.Translational andrology and urology · 2026Article
- Association of the skeletal muscle mass-to-visceral fat area ratio with cardiovascular disease: a cross-sectional study based on NHANES.Eating and weight disorders : EWD · 2026Article
- 3D body shape-based phenotyping for precision risk stratification of metabolic syndrome.Lipids in health and disease · 2026Article
- Observational
- Association between creatinine-to-body weight ratio and incident prediabetes in Chinese adults: a large-scale retrospective cohort study.Frontiers in endocrinology · 2026Article
- Association between creatinine-to-body weight ratio and arterial stiffness: a cross-sectional and longitudinal study in the Chinese population.Frontiers in cardiovascular medicine · 2026Article
- Concurrent Exercise Training Adaptations Over 16 Weeks in Sedentary, Middle- Aged Adults With and Without Post-Exercise Peanut Butter Consumption.International journal of exercise science · 2026Article
- Predictive Modeling of Weight Loss and Metabolic Health Outcomes: A Retrospective Predictive Modeling Study.Health science reports · 2025Article
- Association between sarcopenia and components of metabolic syndrome among Chinese older adults: a population-based longitudinal study using CHARLS.BMC public health · 2025Article
- Article
- From muscle quality to metabolic health: investigating the association between muscle quality index and metabolic syndrome in adults.Diabetology & metabolic syndrome · 2025Article
- Relationship between depression improvement and activities of daily living recovery in patients with fractures.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Normalized Creatinine-to-Cystatin C Ratio and Risk of Cardiometabolic Multimorbidity in Middle-Aged and Older Adults: Insights from the China Health and Retirement Longitudinal Study.Diabetes & metabolism journal · 2025Article
- Fully hydrogenated vegetable oil-based non-dairy creamer intake impairs athletic performance in mice: serum metabolomics and intestinal microbiota analyses.Frontiers in nutrition · 2025Article
- Association between the skeletal muscle-to-visceral fat ratio and kidney stones: a cross-sectional study.Frontiers in nutrition · 2025Article
- Body composition as a complementary tool for detection of metabolic syndrome 6 years postpartum: a St. Carlos Cohort follow-up.Frontiers in nutrition · 2025Article
- Article
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Authors and funding
11 authors.
Funding
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Abstract
backgroundSkeletal muscle mass was negatively associated with metabolic syndrome prevalence in previous cross-sectional studies. The aim of this study was to investigate the impact of baseline skeletal muscle mass and changes in skeletal muscle mass over time on the development of metabolic syndrome in a large population-based 7-year cohort study.
methodsA total of 14,830 and 11,639 individuals who underwent health examinations at the Health Promotion Center at Samsung Medical Center, Seoul, Korea were included in the analyses of baseline skeletal muscle mass and those changes from baseline over 1 year, respectively. Skeletal muscle mass was estimated by bioelectrical impedance analysis and was presented as a skeletal muscle mass index (SMI), a body weight-adjusted appendicular skeletal muscle mass value. Using Cox regression models, hazard ratio for developing metabolic syndrome associated with SMI values at baseline or changes of SMI over a year was analyzed.
resultsDuring 7 years of follow-up, 20.1% of subjects developed metabolic syndrome. Compared to the lowest sex-specific SMI tertile at baseline, the highest sex-specific SMI tertile showed a significant inverse association with metabolic syndrome risk (adjusted hazard ratio [AHR] = 0.61, 95% confidence interval [CI] 0.54-0.68). Furthermore, compared with SMI changes < 0% over a year, multivariate-AHRs for metabolic syndrome development were 0.87 (95% CI 0.78-0.97) for 0-1% changes and 0.67 (0.56-0.79) for > 1% changes in SMI over 1 year after additionally adjusting for baseline SMI and glycometabolic parameters.
conclusionsAn increase in relative skeletal muscle mass over time has a potential preventive effect on developing metabolic syndrome, independently of baseline skeletal muscle mass and glycometabolic parameters.
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