ArticleBMC musculoskeletal disorders2018
Biomechanical effects of metastasis in the osteoporotic lumbar spine: A Finite Element Analysis.
Article in BMC musculoskeletal disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Clinical performance of implanted devices used in surgical treatment of patients with spinal tumors: a systematic review.BMC musculoskeletal disorders · 2024Pooled it
- Diagnostic accuracy of Mirels score, CT-based Structural Rigidity Analysis, and Finite Element Analysis for predicting impending femoral pathologic fractures in metastatic bone disease: a systematic review.Journal of bone oncology · 2026Review
- A three-dimensional finite element-based biomechanical properties analysis of the 10th thoracic vertebra invaded by bone metastases for clinical procedure optimization.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Fracture Patterns of an Osteolytic Hole Involved Lumbar Vertebra, Assessed for a Case Study by Computational Models.International journal for numerical methods in biomedical engineering · 2026Article
- Optimizing Outcomes in Spinal Tumor Surgery: A Meta-analysis Comparing Robotic and Freehand Pedicle Screw Placement.Indian journal of orthopaedics · 2026Review
- Biomechanical effects of different bone conditions on oblique lumbar interbody fusion augmented with various fixation options: a finite element analysis.Frontiers in bioengineering and biotechnology · 2026Article
- Biomechanical study of robot-navigated targeted cross-puncture percutaneous vertebroplasty for Kümmell's disease: finite element analysis.Frontiers in rehabilitation sciences · 2026Article
- Biomechanical effects of defect size and location on vertebral fracture.Journal of medical and biological engineering · 2025Article
- Usage Trends and Safety Profile of Recombinant Human Bone Morphogenetic Protein-2 for Spinal Column Tumor Surgery: A National Matched Cohort Analysis.Global spine journal · 2025Article
- Prediction of vertebral failure under general loadings of compression, flexion, extension, and side-bending.Journal of the mechanical behavior of biomedical materials · 2025Article
- Biomechanical Study of Symmetric Bending and Lifting Behavior in Weightlifter with Lumbar L4-L5 Disc Herniation and Physiological Straightening Using Finite Element Simulation.Bioengineering (Basel, Switzerland) · 2024Article
- Biomechanical study between percutaneous vertebroplasty combined with cement pedicle plasty improves vertebral biomechanical stability: A finite element analysis.BMC musculoskeletal disorders · 2024Article
- Article
- Article
- Second-generation bone cement-injectable cannulated pedicle screws for osteoporosis: biomechanical and finite element analyses.Journal of orthopaedic surgery and research · 2023Article
- Colles' Fracture: An Epidemiological Nationwide Study in Italy from 2001 to 2016.International journal of environmental research and public health · 2023Review
- Biomechanical analysis of sandwich vertebrae in osteoporotic patients: finite element analysis.Frontiers in endocrinology · 2023Article
- Trends in Hospitalization and Economic Impact of Percutaneous Kyphoplasty in Italy.Journal of clinical medicine · 2022Article
- Novel Modular Spine Blocks Affect the Lumbar Spine on Finite Element Analysis.Spine surgery and related research · 2022Article
- Effects of osteoporosis on the biomechanics of various supplemental fixations co-applied with oblique lumbar interbody fusion (OLIF): a finite element analysis.BMC musculoskeletal disorders · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCancer patients are likely to undergo osteoporosis as consequence of hormone manipulation and/or chemotherapy. Little is known about possible increased risk of fracture in this population. The aim of this study was to describe the biomechanical effect of a metastatic lesion in an osteoporotic lumbar spine model.
methodsA finite element model of two spinal motion segments (L3-L5) was extracted from a previously developed L3-Sacrum model and used to analyze the effect of metastasis size and bone mineral density (BMD) on Vertebral bulge (VB) and Vertebral height (VH). VB and VH represent respectively radial and axial displacement and they have been correlated to burst fracture. A total of 6 scenarios were evaluated combining three metastasis sizes (no metastasis, 15% and 30% of the vertebral body) and two BMD conditions (normal BMD and osteoporosis).
results15% metastasis increased VB and VH by 178% and 248%, respectively in normal BMD model; while VB and VH increased by 134% and 174% in osteoporotic model. 30% metastasis increased VB and VH by 88% and 109%, respectively, when compared to 15% metastasis in normal BMD model; while VB and VH increased by 59% and 74% in osteoporotic model.
conclusionA metastasis in the osteoporotic lumbar spine always leads to a higher risk of vertebral fracture. This risk increases with the size of the metastasis. Unexpectedly, an increment in metastasis size in the normal BMD spine produces a greater impact on vertebral stability compared to the osteoporotic spine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.