ReviewAntioxidants (Basel, Switzerland)2018
Do Coffee Polyphenols Have a Preventive Action on Metabolic Syndrome Associated Endothelial Dysfunctions? An Assessment of the Current Evidence.
Review in Antioxidants (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Coffee, caffeine, and cardiovascular health: navigating risks and benefits-an updated systematic review and meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- Potential of Polyphenols for Improving Sleep: A Preliminary Results from Review of Human Clinical Trials and Mechanistic Insights.Nutrients · 2023Pooled it
- The effect of MIND diet on sleep status, mental health, and serum level of BDNF in overweight/obese diabetic women with insomnia: a randomized controlled trial.Scientific reports · 2025Trial
- Integrated Metabolomic and Microbiome Profiling Reveals Divergent Effects of No- and High-Fat Coffee in Mice.Nutrients · 2026Article
- Bioactive Compounds in Coffee: Metabolism, Bioavailability and Health Effects-A Review.Molecules (Basel, Switzerland) · 2026Review
- Associations Between Coffee Consumption and the Prevalence of Metabolic Syndrome: A Nationwide Cross-Sectional Survey of Taiwanese Adults.Nutrients · 2026Observational
- Polyphenol Degradation Kinetics of Specialty Coffee in Different Presentations.Foods (Basel, Switzerland) · 2025Article
- Association between coffee and tea consumption and the risk of macrovascular complications in type 2 diabetes: a UK Biobank cohort study.Diabetology & metabolic syndrome · 2025Article
- Coffee as a Source of Antioxidants and an Elixir of Youth.Antioxidants (Basel, Switzerland) · 2025Review
- Promiscuity in Polyphenol-Protein Interactions-Monitoring Protein Conformational Change upon Polyphenol-Protein Binding by Nano-Differential Fluorimetry (Nano-DSF).Molecules (Basel, Switzerland) · 2025Article
- Association between healthy beverage index and healthy beverage score with metabolic syndrome: a cross-sectional study.Journal of nutritional science · 2025Article
- Evaluating the effects of coffee consumption on the structure and function of the heart from multiple perspectives.Frontiers in cardiovascular medicine · 2025Article
- Minimally processed foods have a higher total antioxidant content compared to processed and ultra-processed foods: results from an analysis of 1946 food items.The British journal of nutrition · 2024Article
- Effects of green coffee supplementation on paraoxonase-1 activity and malondialdehyde levels in Iranian women with polycystic ovary syndrome: a randomized clinical trial.Osong public health and research perspectives · 2024Article
- An umbrella review of meta-analysis to understand the effect of coffee consumption and the relationship between stroke, cardiovascular heart disease, and dementia among its global users.Journal of family medicine and primary care · 2024Review
- Article
- Polyphenols mediated attenuation of diabetes associated cardiovascular complications: A comprehensive review.Journal of diabetes and metabolic disorders · 2024Review
- Association of caffeine consumption with all-cause and cause-specific mortality in adult Americans with hypertension.Food science & nutrition · 2024Article
- Polyphenols vs. Caffeine in Coffee from Franchise Coffee Shops: Which Serving of Coffee Provides the Optimal Amount of This Compounds to the Body.Molecules (Basel, Switzerland) · 2024Article
- Effect of Extraction Methods on Aroma Profile, Antioxidant Activity and Sensory Acceptability of Specialty Coffee Brews.Foods (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epidemiologic studies from several countries have found that mortality rates associated with the metabolic syndrome are inversely associated with coffee consumption. Metabolic syndrome can lead to arteriosclerosis by endothelial dysfunction, and increases the risk for myocardial and cerebral infarction. Accordingly, it is important to understand the possible protective effects of coffee against components of the metabolic syndrome, including vascular endothelial function impairment, obesity and diabetes. Coffee contains many components, including caffeine, chlorogenic acid, diterpenes and trigonelline. Studies have found that coffee polyphenols, such as chlorogenic acids, have many health-promoting properties, such as antioxidant, anti-inflammatory, anti-cancer, anti-diabetes, and antihypertensive properties. Chlorogenic acids may exert protective effects against metabolic syndrome risk through their antioxidant properties, in particular toward vascular endothelial cells, in which nitric oxide production may be enhanced, by promoting endothelial nitric oxide synthase expression. These effects indicate that coffee components may support the maintenance of normal endothelial function and play an important role in the prevention of metabolic syndrome. However, results related to coffee consumption and the metabolic syndrome are heterogeneous among studies, and the mechanisms of its functions and corresponding molecular targets remain largely elusive. This review describes the results of studies exploring the putative effects of coffee components, especially in protecting vascular endothelial function and preventing metabolic syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.