Evidence map›Paper›PMID 29401592›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2018

Kir2 inward rectification-controlled precise and dynamic balances between Kir2 and HCN currents initiate pacemaking activity.

Kuihao Chen, Dongchuan Zuo, Sho-Ya Wang, Haijun Chen

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Ion channel trafficking implications in heart failure.Frontiers in cardiovascular medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kuihao ChenDepartment of Biological Sciences, University at Albany, State University of New York, Albany, New York, USA.
Dongchuan ZuoDepartment of Biological Sciences, University at Albany, State University of New York, Albany, New York, USA.
Sho-Ya WangDepartment of Biological Sciences, University at Albany, State University of New York, Albany, New York, USA.
Haijun ChenDepartment of Biological Sciences, University at Albany, State University of New York, Albany, New York, USA.
Albany State University · US

Funding

Dynamic ion selectivity of K2P channels and paradoxical depolarizationR01GM102943 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI CHEN, HAIJUN · 2012 to 2016
$1.4M
NIGMS NIH HHS R01 GM102943
6 · The paper itself

Abstract

Spontaneous rhythmic action potential or pacemaking activity of pacemaker cells controls rhythmic signaling such as heartbeat. The mechanism underlying the origin of pacemaking activity is not well understood. In this study, we created human embryonic kidney (HEK) 293 cells that show pacemaking activity through heterologous expression of strong inward rectifier K

Indexed as

Action PotentialsBiological ClocksCalcium Channels, T-TypeHEK293 CellsHumansHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsNAV1.5 Voltage-Gated Sodium ChannelPotassium Channels, Inwardly RectifyingCACNA1G protein, humanCalcium Channels, T-TypeHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsKCNJ2 protein, humanNAV1.5 Voltage-Gated Sodium ChannelPotassium Channels, Inwardly RectifyingSCN5A protein, humanHCN channelsKir2.1 channelspacemaker cellsspontaneous rhythmic action potential

Identifiers

PMID29401592
PMCPMC5956248
OpenAlexW2793360998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.