ArticleBiophysical journal2018
Active Prestress Leads to an Apparent Stiffening of Cells through Geometrical Effects.
Article in Biophysical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Multiplexed Single-Cell Rheology Probing Using Surface Acoustic Waves.Small science · 2024Article
- Appetizer on soft matter physics concepts in mechanobiology.Development, growth & differentiation · 2023Review
- EMT changes actin cortex rheology in a cell-cycle-dependent manner.Biophysical journal · 2021Article
- The plastic cell: mechanical deformation of cells and tissues.Open biology · 2021Review
- EMT-Induced Cell-Mechanical Changes Enhance Mitotic Rounding Strength.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Environmentally controlled magnetic nano-tweezer for living cells and extracellular matrices.Scientific reports · 2020Article
- Review
- Elastic Anisotropy Governs the Range of Cell-Induced Displacements.Biophysical journal · 2020Article
- A minimal-length approach unifies rigidity in underconstrained materials.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Vimentin Diversity in Health and Disease.Cells · 2018Review
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Authors and funding
1 author.
Funding
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Abstract
Tuning of active prestress, e.g., through activity of molecular motors, constitutes a powerful cellular tool to adjust cellular stiffness through nonlinear material properties. Understanding this tool is an important prerequisite for our comprehension of cellular force response, cell shape dynamics, and tissue organization. Experimental data obtained from cell-mechanical measurements often show a simple linear dependence between mechanical prestress and measured differential elastic moduli. Although these experimental findings could point to stress-induced structural changes in the material, we propose a surprisingly simple alternative explanation in a theoretical study. We show how geometrical effects can give rise to increased cellular force response of cells in the presence of active prestress. The associated effective stress-stiffening is disconnected from actual stress-induced changes of the elastic modulus, and should therefore be regarded as an apparent stiffening of the material. We argue that new approaches in experimental design are necessary to separate this apparent stress-stiffening due to geometrical effects from actual nonlinearities of the elastic modulus in prestressed cellular material.
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