ArticleJournal of the American Chemical Society2018
Metabolomic "Dark Matter" Dependent on Peroxisomal β-Oxidation in Caenorhabditis elegans.
Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed, 79 citations in OpenAlex.
- Assessing the metabolomics "dark matter" by a detectable khipu model.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Comprehensive Curation and Harmonization of Small-Molecule MS/MS Libraries in Spectraverse.Analytical chemistry · 2026Article
- Expression, purification, and in vitro characterization of the carboxylesterase CEST-9.2 from Caenorhabditis elegans.Bioscience reports · 2026Article
- Cyclohexyl acetate functions like a volatile sex pheromone mimic in Caenorhabditis nematodes.BMC biology · 2026Article
- Biosynthesis of modular signaling molecules requires functional diversification of carboxylesterases in Pristionchus pacificus.Communications biology · 2025Article
- Comparative Metabolomics Identifies the Roles of Acyl-CoA Oxidases in the Biosynthesis of Ascarosides and a Complex Family of SecretedACS chemical biology · 2025Article
- Circular van Krevelen diagram for visualizing metabolic pathways.bioRxiv : the preprint server for biology · 2025Article
- High Nutritional Conditions Influence Feeding Plasticity in Pristionchus pacificus and Render Worms Non-Predatory.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Article
- Surface Lipids in Nematodes are Influenced by Development and Species-specific Adaptations.Journal of the American Chemical Society · 2025Article
- On collective behavior inFrontiers in neurorobotics · 2025Review
- Navigating common pitfalls in metabolite identification and metabolomics bioinformatics.Metabolomics : Official journal of the Metabolomic Society · 2024Review
- Ascarosides and Symbiotic Bacteria of Entomopathogenic Nematodes Regulate Host Immune Response inInsects · 2024Article
- The nematode-trapping fungus Arthrobotrys oligospora detects prey pheromones via G protein-coupled receptors.Nature microbiology · 2024Article
- Acylspermidines are conserved mitochondrial sirtuin-dependent metabolites.Nature chemical biology · 2024Article
- Peripheral peroxisomal β-oxidation engages neuronal serotonin signaling to drive stress-induced aversive memory in C. elegans.Cell reports · 2024Article
- Pheromone-based communication influences the production of somatic extracellular vesicles in C. elegans.Nature communications · 2024Article
- LIPID MAPS: update to databases and tools for the lipidomics community.Nucleic acids research · 2024Article
- Natural genetic variation in the pheromone production ofProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Capillary electrophoresis-mass spectrometry as a tool for Caenorhabditis elegans metabolomics research.Metabolomics : Official journal of the Metabolomic Society · 2023Article
- Repurposing degradation pathways for modular metabolite biosynthesis in nematodes.Nature chemical biology · 2023Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Peroxisomal β-oxidation (pβo) is a highly conserved fat metabolism pathway involved in the biosynthesis of diverse signaling molecules in animals and plants. In Caenorhabditis elegans, pβo is required for the biosynthesis of the ascarosides, signaling molecules that control development, lifespan, and behavior in this model organism. Via comparative mass spectrometric analysis of pβo mutants and wildtype, we show that pβo in C. elegans and the satellite model P. pacificus contributes to life stage-specific biosynthesis of several hundred previously unknown metabolites. The pβo-dependent portion of the metabolome is unexpectedly diverse, e.g., intersecting with nucleoside and neurotransmitter metabolism. Cell type-specific restoration of pβo in pβo-defective mutants further revealed that pβo-dependent submetabolomes differ between tissues. These results suggest that interactions of fat, nucleoside, and other primary metabolism pathways can generate structural diversity reminiscent of that arising from combinatorial strategies in microbial natural product biosynthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.