ArticleACS chemical biology2018
The Effects of Ultraviolet Radiation on Nucleoside Modifications in RNA.
Article in ACS chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- tRNA-modifying enzymes in bacterial stress adaptation.Open biology · 2025Review
- Article
- Stress-induced modification ofProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Oxidative stress responses in biofilms.Biofilm · 2024Review
- Characterizing RNA Modifications in Single Neurons Using Mass Spectrometry.Journal of visualized experiments : JoVE · 2022Article
- Ionizing radiation and chemical oxidant exposure impacts on Cryptococcus neoformans transfer RNAs.PloS one · 2022Article
- Single-Neuron RNA Modification Analysis by Mass Spectrometry: Characterizing RNA Modification Patterns and Dynamics with Single-Cell Resolution.Analytical chemistry · 2021Article
- Bacterial Response to Oxidative Stress and RNA Oxidation.Frontiers in genetics · 2021Review
- Oxidative Stress in Bacteria and the Central Dogma of Molecular Biology.Frontiers in molecular biosciences · 2021Review
- Oxidative Damage to RNA is Altered by the Presence of Interacting Proteins or Modified Nucleosides.Frontiers in molecular biosciences · 2021Article
- Characterization of UVA-Induced Alterations to Transfer RNA Sequences.Biomolecules · 2020Article
- Review
- Oligonucleotide analysis by hydrophilic interaction liquid chromatography-mass spectrometry in the absence of ion-pair reagents.Journal of chromatography. A · 2019Article
- Detection of ribonucleoside modifications by liquid chromatography coupled with mass spectrometry.Biochimica et biophysica acta. Gene regulatory mechanisms · 2019Review
- A Chemical Signature for Cytidine Acetylation in RNA.Journal of the American Chemical Society · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Ultraviolet radiation (UVR) is a known genotoxic agent. Although its effects on DNA have been well-documented, its impact on RNA and RNA modifications is less studied. By using Escherichia coli tRNA (tRNA) as a model system, we identify the UVA (370 nm) susceptible chemical groups and bonds in a large variety of modified nucleosides. We use liquid chromatography tandem mass spectrometry to identify specific nucleoside photoproducts under in vitro and in vivo conditions, which were then verified by employing stable-isotope labeled tRNAs. These studies suggest that the -amino or -oxy groups of modified nucleosides, in addition to sulfur, are labile in the oxidative environment generated by UVA exposure. Further, these studies document a range of RNA photoproducts and post-transcriptional modifications that arise because of UVR-induced cellular stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.