Evidence map›Paper›PMID 29400707›Full record

ArticleCellular & molecular immunology2019

IL-33 induces immunosuppressive neutrophils via a type 2 innate lymphoid cell/IL-13/STAT6 axis and protects the liver against injury in LCMV infection-induced viral hepatitis.

Yuejin Liang, Panpan Yi, Denley Ming Kee Yuan, Zuliang Jie, Zakari Kwota, Lynn Soong, Yingzi Cong, Jiaren Sun

Open access · bronzeAbstract read
In one paragraph

Article in Cellular & molecular immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yuejin LiangDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, 77555-1070, USA, TX. yu2liang@utmb.edu.
Panpan YiDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, 77555-1070, USA, TX.
Denley Ming Kee YuanDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, 77555-1070, USA, TX.
Zuliang JieDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, 77555-1070, USA, TX.
Zakari KwotaDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, 77555-1070, USA, TX.
Lynn SoongDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, 77555-1070, USA, TX.
Yingzi CongDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, 77555-1070, USA, TX.
Jiaren SunDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, 77555-1070, USA, TX. jisun@utmb.edu.
The University of Texas Medical Branch at Galveston · USXiangya Hospital Central South University · CN

Funding

Infectious Diseases and Inflammatory Disorders Training ProgramT35AI078878 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WANG, TIAN · 2008 to 2025
$701k
Retinoic Acid Regulates S100 Proteins and Immune Responses in Viral HepatitisR21AI126371 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SUN, JIAREN · 2016 to 2017
$426k
Damage-associated Alarmin Key to Immune Responses in Viral HepatitisR21AI109100 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SUN, JIAREN · 2014 to 2015
$426k
NIAID NIH HHS R21 AI109100NIAID NIH HHS R21 AI126371NIAID NIH HHS T35 AI078878
6 · The paper itself

Abstract

Viral hepatitis is still a public health problem affecting several million people around the world. Neutrophils are polymorphonuclear cells that have a critical role in antibacterial infection. However, the role of neutrophils in viral infection is not fully understood. By using a mouse model of lymphocytic choriomeningitis virus infection-induced viral hepatitis, we observed increased neutrophil recruitment in the liver accompanied by enhanced CD8

Indexed as

AnimalsArginaseCytokinesHepatitis, Viral, AnimalImmunity, InnateIncidenceInterleukin-13Interleukin-33LiverLymphocyte ActivationLymphocytesLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMiceMice, Inbred C57BLNeutrophilsArg1 protein, mouseArginaseCytokinesIl33 protein, mouseInterleukin-13Interleukin-33Stat6 protein, mouseSTAT6 Transcription Factor

Identifiers

PMID29400707
PMCPMC6355846
OpenAlexW2790753782

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.