ArticlePhotonics research2017
Coherent optical adaptive technique improves the spatial resolution of STED microscopy in thick samples.
Article in Photonics research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Large intra-chromosome heterogeneity leads to emergent nonlinear mechanics.Nature physics · 2026Article
- Ultralow Laser Power Three-Dimensional Superresolution Microscopy Based on Digitally Enhanced STED.Biosensors · 2022Article
- Low-Power Two-Color Stimulated Emission Depletion Microscopy for Live Cell Imaging.Biosensors · 2021Article
- Article
- Super-resolution Microscopy for Biological Imaging.Advances in experimental medicine and biology · 2021Review
- Increasing fluorescence lifetime for resolution improvement in stimulated emission depletion nanoscopy.Journal of biophotonics · 2019Article
- Full volume super-resolution imaging of thick mitotic spindle using 3D AO STED microscope.Biomedical optics express · 2019Article
- Aberration correction for improving the image quality in STED microscopy using the genetic algorithm.Nanophotonics (Berlin, Germany) · 2018Article
- Imaging through scattering media with the auxiliary of a known reference object.Scientific reports · 2018Article
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Authors and funding
7 authors.
Funding
Abstract
Stimulated emission depletion microscopy (STED) is one of far-field optical microscopy techniques that can provide sub-diffraction spatial resolution. The spatial resolution of the STED microscopy is determined by the specially engineered beam profile of the depletion beam and its power. However, the beam profile of the depletion beam may be distorted due to aberrations of optical systems and inhomogeneity of specimens' optical properties, resulting in a compromised spatial resolution. The situation gets deteriorated when thick samples are imaged. In the worst case, the sever distortion of the depletion beam profile may cause complete loss of the super resolution effect no matter how much depletion power is applied to specimens. Previously several adaptive optics approaches have been explored to compensate aberrations of systems and specimens. However, it is hard to correct the complicated high-order optical aberrations of specimens. In this report, we demonstrate that the complicated distorted wavefront from a thick phantom sample can be measured by using the coherent optical adaptive technique (COAT). The full correction can effectively maintain and improve the spatial resolution in imaging thick samples.
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Registered trials
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