ArticleThe Annals of pharmacotherapy2018
Association of Statin Therapy With Risk of Epilepsy in 2 Propensity Score-Matched Cohorts.
Article in The Annals of pharmacotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Clinical outcomes and unmet therapeutic needs in new-onset refractory status epilepticus: evidence from a retrospective cohort.Neurological research and practice · 2026Article
- Effects of lipid-lowering drugs on epilepsy and its subtypes: A drug-target Mendelian randomization study.Medicine · 2026Article
- Statins' protective effects on focal epilepsy are independent of LDL-C.Epilepsia open · 2025Article
- Mechanistic insights into the sleep-glymphopathy-cerebral small vessel disease loop: implications for epilepsy pathophysiology and therapy.Frontiers in neuroscience · 2025Review
- Beneficial Effects of Statins on Seizures Independent of Their Lipid-Lowering Effect: A Narrative Review.Iranian journal of medical sciences · 2023Review
- Statins as antiepileptogenic drugs: Analyzing the evidence and identifying the most promising statin.Epilepsia · 2022Review
- Associations between statin use and suicidality, depression, anxiety, and seizures: a Swedish total-population cohort study.The lancet. Psychiatry · 2020Article
- The Effect of Statins in Epilepsy: A Systematic Review.Journal of neurosciences in rural practiceArticle
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundStudies have suggested that statins may have a neuroprotective effect against epilepsy. However, evidence from rat models and case reports have suggested an opposite effect. Overall data are limited.
objectiveTo examine the association between statin use and epilepsy risk in a general population and in a healthy population (individuals with no severe comorbidities).
methodsPatients were Tricare beneficiaries from October 2003 to March 2012. Based on patients' characteristics during baseline phase (fiscal year [FY] 2004-2005), 2 propensity score (PS)-matched cohorts of statin users and nonusers were formed: (1) a PS-matched general cohort and (2) a PS-matched healthy cohort. Our outcome was defined using inpatient or outpatient ICD-9 codes for epilepsy during the follow-up phase (FY 2006 to March 2012) in the cohorts of statin users and nonusers.
resultsThe study included a total of 43 438 patients (13 626 statin users and 29 812 nonusers). The PS-matched general cohort matched 6342 statin users to 6342 nonusers; the odds ratio (OR) of epilepsy in this cohort during follow-up was 0.91; 95% CI = 0.67-1.23. The PS-matched healthy cohort matched 3351 statin users to 3351 nonusers; OR in the PS-matched healthy cohort during follow-up was 1.08; 95% CI = 0.64-1.83.
conclusionsThis study did not demonstrate a significant beneficial or deleterious effect of statin use on risk of being diagnosed with epilepsy. Clinicians should not withhold statins, whenever indicated, in patients with epilepsy.
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