ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2018
Adaptive behavior in infants and toddlers with Down syndrome and fragile X syndrome.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Sex-specific developmental phenotypes and their response to neonatalbioRxiv : the preprint server for biology · 2026Article
- Prelinguistic Communication Complexity of Children With Neurogenetic Syndromes.Journal of speech, language, and hearing research : JSLHR · 2025Article
- A Comparison of Developmental Profiles of Preschool Children with Down Syndrome, Global Developmental Delay, and Developmental Language Disorder.Healthcare (Basel, Switzerland) · 2025Article
- Article
- Exploring the feasibility and effectiveness of a naturalistic family centered intervention to enhance early interactions in toddlers with Down syndrome.Scientific reports · 2025Article
- X- vs. Y-chromosome influences on human behavior: a deep phenotypic comparison of psychopathology in XXY and XYY syndromes.Journal of neurodevelopmental disorders · 2024Article
- Developmental associations between motor and communication outcomes in Fragile X syndrome: Variation in the context of co-occurring autism.Autism : the international journal of research and practice · 2024Article
- Developmental associations between cognition and adaptive behavior in intellectual and developmental disability.Journal of neurodevelopmental disorders · 2024Article
- Developmental Profile in Children Aged 3-6 Years: Down Syndrome vs. Autism Spectrum Disorder.Behavioral sciences (Basel, Switzerland) · 2024Article
- Developmental Associations between Cognition and Adaptive Behavior in Intellectual and Developmental Disability.Research square · 2024Article
- Considerations for developing syndrome-informed early interventions for children with neurogenetic conditions.International review of research in developmental disabilities · 2024Article
- Development, education, and services in children with Down syndrome: a cohort analysis from a clinical database.Frontiers in psychology · 2024Article
- Insomnia Symptoms Are Associated with Measures of Functional Deterioration and Dementia Status in Adults with Down Syndrome at High Risk for Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Article
- Clinical practice - latest insights in optimizing the care of children with Down syndrome.European journal of pediatrics · 2023Review
- The activation of mGluR4 rescues parallel fiber synaptic transmission and LTP, motor learning and social behavior in a mouse model of Fragile X Syndrome.Molecular autism · 2023Article
- Developmental Coordination Disorder and Most Prevalent Comorbidities: A Narrative Review.Children (Basel, Switzerland) · 2022Review
- Patterns and predictors of adaptive skills in 2- to 7-year-old children with Down syndrome.Journal of neurodevelopmental disorders · 2022Article
- Executive functions and adaptive behaviour in individuals with Down syndrome.Journal of intellectual disability research : JIDR · 2022Article
- Motor Influences on Communication: Comparisons Between Down Syndrome and Fragile X Syndrome.American journal on intellectual and developmental disabilities · 2021Article
- The role of distinct executive functions on adaptive behavior in children and adolescents with Down syndrome.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Individuals with Down syndrome (DS) experience deficits across all domains of adaptive functioning, however little is known about the emergence and age-related changes of these impairments compared to other neurogenetic disorders with similar intellectual disability impairments, such as fragile X syndrome (FXS). Adaptive behavior is key for optimal functioning in these populations. Participants aged 5-45 months comprised three age-matched groups, DS (n = 64), FXS (n = 69), and typically developing controls (TD; n = 69). Adaptive behavior was measured on the Vineland Adaptive Behavior Scales-II. Regressions were used to examine adaptive behavior in a cross-sectional design across age. DS infants and toddlers evidenced deficits across all areas of adaptive behaviors compared to the age-matched TD group, with clear impairments present in the first year of life. Motor skills were the area of greatest weakness in children with DS with significant impairment evident at 12 months of age that remained low through 3 years. Compared to age-matched children with FXS, children with DS showed initially lower standard scores at 12 months of age, but slower declines in standard scores across age, resulting in less impaired functioning at 36 months. This is the first study to compare adaptive behavior in infants and toddlers with DS to FXS, and demonstrate the phenotypic specificity of adaptive profiles in this diagnostic group. These findings provide evidence that adaptive behavior should be a major target of intervention in children with FXS and DS, and that these differences are potentially driven by unique etiologies attributable to each disorder.
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