Evidence map›Paper›PMID 29399750›Full record

ArticleCardiology journal2019

Implantable loop recorders in patients with unexplained syncope: Clinical predictors of pacemaker implantation.

Martin Huemer, Ann-Kristin Becker, Alexander Wutzler, Philipp Attanasio, Abdul S Parwani, Philipp Lacour, Leif-Hendrik Boldt, Burkert Pieske, Wilhelm Haverkamp, Florian Blaschke

Abstract read
In one paragraph

Article in Cardiology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Observational
  5. Implantable loop recorder migration: Case-based review and implications for clinical practice.American heart journal plus : cardiology research and practice · 2025
    Article
  6. Review
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Diagnostic value of implantable loop recorders in patients with unexplained syncope or palpitations.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2021
    Observational
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Martin HuemerDepartment of Cardiology, Campus Virchow-Klinikum, Charité - University Medicine Berlin, Germany.
Ann-Kristin BeckerDepartment of Cardiology, Campus Virchow-Klinikum, Charité - University Medicine Berlin, Germany.
Alexander WutzlerDepartment of Cardiology, Campus Virchow-Klinikum, Charité - University Medicine Berlin, Germany.
Philipp AttanasioDepartment of Cardiology, Campus Virchow-Klinikum, Charité - University Medicine Berlin, Germany.
Abdul S ParwaniDepartment of Cardiology, Campus Virchow-Klinikum, Charité - University Medicine Berlin, Germany.
Philipp LacourDepartment of Cardiology, Campus Virchow-Klinikum, Charité - University Medicine Berlin, Germany.
Leif-Hendrik BoldtDepartment of Cardiology, Campus Virchow-Klinikum, Charité - University Medicine Berlin, Germany.
Burkert PieskeDepartment of Cardiology, Campus Virchow-Klinikum, Charité - University Medicine Berlin, Germany.
Wilhelm HaverkampDepartment of Cardiology, Campus Virchow-Klinikum, Charité - University Medicine Berlin, Germany.
Florian BlaschkeDepartment of Cardiology, Campus Virchow-Klinikum, Charité - University Medicine Berlin, Germany. florian.blaschke@charite.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImplantable loop recorders (ILR) are a valuable tool for the investigation of unexplainedsyncopal episodes. The aim of this retrospective single center study was to identify predictive factors for pacemaker implantation in patients with unexplained syncope who underwent ILR insertion.

methodsOne hundred six patients were retrospectively analyzed (mean age 59.1 years; 47.2% male) with unexplained syncope and negative conventional testing who underwent ILR implantation. The pri- mary study endpoint was detection of symptomatic or asymptomatic bradycardia requiring pacemaker implantation.

resultsThe average follow-up period after ILR implantation was 20 ± 15 months. Pacemaker im- plantation according to current guidelines was necessary in 22 (20.8%) patients, mean duration until index bradycardia was 81 ± 88 (2-350) days. Ten (45.5%) patients received a pacemaker due to sinus arrest, 7 (31.8%) patients due to third-degree atrioventricular block, 2 (9.1%) patients due to second- degree atrioventricular block and 1 (4.5%) patient due to atrial fibrillation with a slow ventricular rate. Three factors remained significant in multivariate analysis: obesity, which defined by a body mass index above 30 kg/m2 (OR: 7.39, p = 0.014), a right bundle branch block (OR: 9.40, p = 0.023) and chronic renal failure as defined by a glomerular filtration rate of less than 60 mL/min (OR: 6.42, p = 0.035).

conclusionsBradycardia is a frequent finding in patients undergoing ILR implantation due to un- explained syncope. Obesity, right bundle branch block and chronic renal failure are independent clinical predictors of pacemaker implantation.

Indexed as

Electrodes, ImplantedAdultAgedAged, 80 and overCardiac Pacing, ArtificialElectrocardiography, AmbulatoryFemaleFollow-Up StudiesHumansMaleMiddle AgedPredictive Value of TestsRetrospective StudiesSyncopeTime FactorsYoung Adultimplantable loop recorderpacemakerunexplained syncope

Identifiers

PMID29399750
PMCPMC8086690

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.