ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2018
Acute hepatitis E in India appears to be caused exclusively by genotype 1 hepatitis E virus.
Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Asian Pacific Association for the Study of the Liver clinical practice guidelines on liver transplantation.Hepatology international · 2024Guideline
- Clinical Guidelines for Hepatitis E Vaccination in India: An Expert Panel Consensus Report on the Recombinant Hepatitis E Vaccine, HEV 239.Pathogens (Basel, Switzerland) · 2026Review
- Epidemiology of Hepatitis E.Advances in experimental medicine and biology · 2023Article
- Transfusion-transmitted hepatitis E: What we know so far?World journal of gastroenterology · 2022Review
- Hepatitis E: Current Status in India.Clinical liver disease · 2021Review
- Review
- A Superinfection of Salmonella typhi and Hepatitis E Virus Causes Biphasic Acute Hepatitis.Internal medicine (Tokyo, Japan) · 2021Article
- Acute Liver Failure During Pregnancy: Happy to Recover from Hep E.Digestive diseases and sciences · 2020Article
- Article
- Population density and water balance influence the global occurrence of hepatitis E epidemics.Scientific reports · 2019Article
- Antibody and Memory B Cell Responses in Hepatitis E Recovered Individuals, 1-30 Years Post Hepatitis E Virus Infection.Scientific reports · 2019Article
- Response to: 'Chronic genotype 1 hepatitis E infection from immunosuppression for ileo-colonic Crohn's disease'.Oxford medical case reports · 2019Article
- Prevalence of hepatitis E virus viremia and antibodies among healthy blood donors in India.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2018Article
- Indian National Association for the Study of the Liver-Federation of Obstetric and Gynaecological Societies of India Position Statement on Management of Liver Diseases in Pregnancy.Journal of clinical and experimental hepatologyReview
- Indian National Association for the Study of the Liver Consensus Statement on Acute Liver Failure (Part 1): Epidemiology, Pathogenesis, Presentation and Prognosis.Journal of clinical and experimental hepatologyReview
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatitis E is caused by infection with hepatitis E virus (HEV), which has four well-known genotypes. Genotypes 1 and 2 HEV have been reported from human cases in areas where the disease is highly endemic. By contrast, genotypes 3 and 4 HEV, which primarily infect several animal species worldwide, have been reported mainly from sporadic human cases in non-endemic areas such as Japan and high-income countries of Europe and North America. To determine whether genotype 3/4 HEV cause sporadic disease in India, a disease-endemic area, we determined HEV genotype in a group of patients with such disease.
methodsA part of the HEV open reading frame (ORF) 1 was amplified and sequenced from sera of 74 patients with sporadic acute viral hepatitis E from four cities in India. The sequences were compared with prototype sequences for various HEV genotypes and subgenotypes and analyzed using phylogenetic tools to determine the genotype of the isolates. For 12 specimens, a part of HEV ORF2 was also similarly analyzed.
resultsPartial ORF1 sequences of all the 74 isolates belonged to genotype 1 HEV, with 88.2% to 100% nucleotide identity with the prototype genotype 1 isolates. Partial ORF2 sequences for all the 12 isolates also belonged to genotype 1 HEV. On phylogenetic analysis, 71 isolates clustered with prototype genotype 1a HEV; the remaining three isolates were located between subgenotypes 1a and 1c but were closer to the former.
conclusionHuman sporadic acute hepatitis E in India is caused almost exclusively by genotype 1 HEV.
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