Evidence map›Paper›PMID 29399654›Full record

ArticleACS omega2018

Size-Dependent Inhibitory Effects of Antibiotic Drug Nanocarriers against

Feng Ding, Preeyaporn Songkiatisak, Pavan Kumar Cherukuri, Tao Huang, Xiao-Hong Nancy Xu

Abstract read
In one paragraph

Article in ACS omega, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Promising Therapeutic Strategies Against Microbial Biofilm Challenges.Frontiers in cellular and infection microbiology · 2020
    Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Feng DingDepartment of Chemistry and Biochemistry, Old Dominion University, Norfolk, Virginia 23529, United States.
Preeyaporn SongkiatisakDepartment of Chemistry and Biochemistry, Old Dominion University, Norfolk, Virginia 23529, United States.
Pavan Kumar CherukuriDepartment of Chemistry and Biochemistry, Old Dominion University, Norfolk, Virginia 23529, United States.
Tao HuangDepartment of Chemistry and Biochemistry, Old Dominion University, Norfolk, Virginia 23529, United States.
Xiao-Hong Nancy XuDepartment of Chemistry and Biochemistry, Old Dominion University, Norfolk, Virginia 23529, United States.

Funding

Nanoassay for Realtime Molecular Probing ABC TransporterR01GM076440 · NIGMS · OLD DOMINION UNIVERSITY · PI XU, X. NANCY · 2006 to 2010
$1.7M
New Photostable Nanoprobes for Real-time Imaging of Single Live CellsR15GM119116 · NIGMS · OLD DOMINION UNIVERSITY · PI XU, X. NANCY · 2016 to 2017
$555k
Photostable Multiplexing NanoAssays for Real-Time Study of Embryonic Stem CellsR21HL127580 · NHLBI · OLD DOMINION UNIVERSITY · PI XU, X. NANCY · 2015 to 2016
$426k
NHLBI NIH HHS R21 HL127580NIGMS NIH HHS R01 GM076440NIGMS NIH HHS R15 GM119116
6 · The paper itself

Abstract

Multidrug membrane transporters (efflux pumps) are responsible for multidrug resistance (MDR) and the low efficacy of therapeutic drugs. Noble metal nanoparticles (NPs) possess a high surface-area-to-volume ratio and size-dependent plasmonic optical properties, enabling them to serve both as imaging probes to study sized-dependent MDR and as potential drug carriers to circumvent MDR and enhance therapeutic efficacy. To this end, in this study, we synthesized three different sizes of silver nanoparticles (Ag NPs), 2.4 ± 0.7, 13.0 ± 3.1, and 92.6 ± 4.4 nm, functionalized their surface with a monolayer of 11-amino-1-undecanethiol (AUT), and covalently conjugated them with antibiotics (ofloxacin, Oflx) to prepare antibiotic drug nanocarriers with conjugation ratios of 8.6 × 10

Identifiers

PMID29399654
PMCPMC5793034

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.