Evidence map›Paper›PMID 29399408›Full record

ArticleOncoimmunology

Oncolytic viruses sensitize human tumor cells for NY-ESO-1 tumor antigen recognition by CD4+ effector T cells.

Tiphaine Delaunay, Mathilde Violland, Nicolas Boisgerault, Soizic Dutoit, Virginie Vignard, Christian Münz, Monique Gannage, Brigitte Dréno, Kristine Vaivode, Dace Pjanova and 9 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 7 countries.

Tiphaine DelaunayCRCINA, INSERM, Université d'Angers, Université de Nantes, Nantes, France.
Mathilde ViollandCRCINA, INSERM, Université d'Angers, Université de Nantes, Nantes, France.
Nicolas BoisgeraultCRCINA, INSERM, Université d'Angers, Université de Nantes, Nantes, France.
Soizic DutoitCRCINA, INSERM, Université d'Angers, Université de Nantes, Nantes, France.
Virginie VignardCRCINA, INSERM, Université d'Angers, Université de Nantes, Nantes, France.
Christian MünzInstitute of Experimental Immunology, University of Zürich, Switzerland.
Monique GannageInstitute of Experimental Immunology, University of Zürich, Switzerland.
Brigitte DrénoCRCINA, INSERM, Université d'Angers, Université de Nantes, Nantes, France.
Kristine VaivodeLatvian Biomedical Research and Study Centre, Riga, Latvia.
Dace PjanovaLatvian Biomedical Research and Study Centre, Riga, Latvia.
Nathalie LabarrièreCRCINA, INSERM, Université d'Angers, Université de Nantes, Nantes, France.
Yaohe WangCentre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.
E Antonio ChioccaHarvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Fabrice Le BoeufCenter for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Canada.
John C BellCenter for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Canada.
Philippe ErbsTransgene, Illkirch, France.
Frédéric TangyUnité de Génomique Virale et Vaccination, Institut Pasteur, CNRS UMR-3569, Paris, France.
Marc GrégoireCRCINA, INSERM, Université d'Angers, Université de Nantes, Nantes, France.
Jean-François FonteneauCRCINA, INSERM, Université d'Angers, Université de Nantes, Nantes, France.
Nantes Université · FRInserm · FRLatvian Biomedical Research and Study Centre · LVUniversité d'Angers · FRUniversity of Zurich · CHBrigham and Women's Hospital · USInstitut Pasteur · FROttawa Hospital Research InstituteQueen Mary University of London · GBTransgene (France) · FRUniversity of Ottawa · CA

Funding

Medical Research Council MR/M015696/1
6 · The paper itself

Abstract

Oncolytic immunotherapy using oncolytic viruses (OV) has been shown to stimulate the antitumor immune response by inducing the release of tumor-associated antigens (TAA) and danger signals from the dying infected tumor cells. In this study, we sought to determine if the lysis of tumor cells induced by different OV: measles virus, vaccinia virus, vesicular stomatitis virus, herpes simplex type I virus, adenovirus or enterovirus, has consequences on the capacity of tumor cells to present TAA, such as NY-ESO-1. We show that the co-culture of NY-ESO-1

Indexed as

CD4+ T LymphocytesMelanomaOncolytic immunotherapyOncolytic VirusesTumor-Associated Antigens

Identifiers

PMID29399408
PMCPMC5790392
OpenAlexW2773596288

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.