Evidence map›Paper›PMID 29399400›Full record

ArticleOncoimmunology

Harnessing innate lung anti-cancer effector functions with a novel bacterial-derived immunotherapy.

Mark Bazett, Amanda M Costa, Momir Bosiljcic, Rebecca M Anderson, Matthew P Alexander, Stephanie W Y Wong, Salim Dhanji, Jenny Mh Chen, Jim Pankovich, Stephen Lam and 4 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05677113 (A Phase II Study of Perioperative QBECO Site Specific Immunomodulator), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05677113 phase2active not recruitingnot on this map

A Phase II Study of Perioperative QBECO Site Specific Immunomodulator (Qu Biologics®) in Patients With Metastatic Colorectal Adenocarcinoma Within the Liver Undergoing Resection

TypeinterventionalSponsorSunnybrook Health Sciences CentreRan2023 to 2031Enrolled115ConditionsColorectal Cancer, Liver MetastasesArmsQBECO, Placebo
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Current advances in microbial-based cancer therapies.Medical oncology (Northwood, London, England) · 2023
    Review
  5. Review
  6. Article
  7. Review
  8. White paper on microbial anti-cancer therapy and prevention.Journal for immunotherapy of cancer · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Mark BazettQu Biologics Inc., Vancouver, BC, V5 T 4T5, Canada.
Amanda M CostaDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Momir BosiljcicQu Biologics Inc., Vancouver, BC, V5 T 4T5, Canada.
Rebecca M AndersonQu Biologics Inc., Vancouver, BC, V5 T 4T5, Canada.
Matthew P AlexanderDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Stephanie W Y WongQu Biologics Inc., Vancouver, BC, V5 T 4T5, Canada.
Salim DhanjiQu Biologics Inc., Vancouver, BC, V5 T 4T5, Canada.
Jenny Mh ChenQu Biologics Inc., Vancouver, BC, V5 T 4T5, Canada.
Jim PankovichQu Biologics Inc., Vancouver, BC, V5 T 4T5, Canada.
Stephen LamBC Cancer Research Center, Vancouver, BC, Canada.
Simon SutcliffeQu Biologics Inc., Vancouver, BC, V5 T 4T5, Canada.
Hal GunnQu Biologics Inc., Vancouver, BC, V5 T 4T5, Canada.
Shirin KalyanQu Biologics Inc., Vancouver, BC, V5 T 4T5, Canada.
David W MullinsDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Dartmouth College · USUniversity of British Columbia · CA

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Center for Molecular, Cellular, and Translational ImmunologyP30GM103415 · NIGMS · DARTMOUTH COLLEGE · PI GREEN, WILLIAM R · 2012 to 2015
$4.7M
Combinational Therapy of Melanoma using T Cells and site-specific ImmunomodulatorsR03CA188418 · NCI · DARTMOUTH COLLEGE · PI MULLINS, DAVID W. · 2015 to 2016
$162k
NCI NIH HHS P30 CA023108NCI NIH HHS R03 CA188418NIGMS NIH HHS P30 GM103415
6 · The paper itself

Abstract

Acute infection is known to induce strong anti-tumor immune responses, but clinical translation has been hindered by the lack of an effective strategy to safely and consistently provoke a therapeutic response. These limitations are overcome with a novel treatment approach involving repeated subcutaneous delivery of a

Indexed as

immunotherapyinnate immunityKlebsiellalung cancerNK cellsNKG2DNSCLC

Identifiers

PMID29399400
PMCPMC5790356
OpenAlexW2767656371

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.