Evidence map›Paper›PMID 29399336›Full record

ArticleBiomedical reports2018

Cardiovascular characteristics of chronic fatigue syndrome.

Sara Bozzini, Andrea Albergati, Enrica Capelli, Lorenzo Lorusso, Carmine Gazzaruso, Gabriele Pelissero, Colomba Falcone

Abstract read
In one paragraph

Article in Biomedical reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Recent research in myalgic encephalomyelitis/chronic fatigue syndrome: an evidence map.Health technology assessment (Winchester, England) · 2025
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. COVID-19 Pandemic: Cardiovascular Complications and Future Implications.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sara BozziniInterdepartmental Center for Research in Molecular Medicine (CIRMC), University of Pavia, I-27100 Pavia, Italy.
Andrea AlbergatiDepartment of Neurology, Istituti Clinici di Pavia e Vigevano, University Hospital, I-27100 Pavia, Italy.
Enrica CapelliDepartment of Earth and Environmental Sciences, University of Pavia, I-27100 Pavia, Italy.
Lorenzo LorussoDepartment of Neurology, Mellino Mellini Hospital, I-25082 Chiari BS, Italy.
Carmine GazzarusoInterdepartmental Center for Research in Molecular Medicine (CIRMC), University of Pavia, I-27100 Pavia, Italy.
Gabriele PelisseroIRCCS San Donato Hospital, San Donato Milanese, I-20097 Milan, Italy.
Colomba FalconeInterdepartmental Center for Research in Molecular Medicine (CIRMC), University of Pavia, I-27100 Pavia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with chronic fatigue syndrome (CFS) commonly exhibit orthostatic intolerance. Abnormal sympathetic predominance in the autonomic cardiovascular response to gravitational stimuli was previously described in numerous studies. The aim of the current study was to describe cardiological and clinical characteristics of Italian patients with CFS. All of the patients were of Caucasian ethnicity and had been referred to our center, the Cardiology Department of the University Hospital of Pavia (Pavia, Italy) with suspected CFS. A total of 44 patients with suspected CFS were included in the present study and the diagnosis was confirmed in 19 patients according to recent clinical guidelines. The characteristics at baseline of the population confirm findings from various previous reports regarding the prevalence in females with a female to male ratio of 4:1, the age of onset of the pathology and the presence of previous infection by the Epstein-Barr virus, cytomegalovirus and other human herpesviruses. Despite the current data indicating that the majority of the cardiological parameters investigated are not significantly different in patients with and without CFS, a significant association between the disease and low levels of blood pressure was identified. Other pilot studies revealed a higher prevalence of hypotension and orthostatic intolerance in patients with CFS. Furthermore, many of the CFS symptoms, including fatigue, vertigo, decreased concentration, tremors and nausea, may be explained by hypotension.

Indexed as

blood pressurecardiological parameterschronic fatigue syndromeepidemiologyorthostatic intolerance

Identifiers

PMID29399336
PMCPMC5772628

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.