ArticleChemical science2018
Metal-dependent allosteric activation and inhibition on the same molecular scaffold: the copper sensor CopY from
Open access · diamondAbstract read
In one paragraph
Article in Chemical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Small Cysteine-Rich Motif, Big Function─Metal-Driven Dimerization of the CopY C-Terminal Fragment.Inorganic chemistry · 2025Article
- Exploring Metalloproteome Remodeling in Calprotectin-StressedACS chemical biology · 2025Article
- Exploring metalloproteome remodeling in calprotectin-stressedbioRxiv : the preprint server for biology · 2025Article
- Bacterial Metallostasis: Metal Sensing, Metalloproteome Remodeling, and Metal Trafficking.Chemical reviews · 2024Review
- An opportunistic pathogen under stress: how Group B Streptococcus responds to cytotoxic reactive species and conditions of metal ion imbalance to survive.FEMS microbiology reviews · 2024Review
- Mis-regulation of Zn and Mn homeostasis is a key phenotype of Cu stress in Streptococcus pyogenes.Metallomics : integrated biometal science · 2023Article
- Linking Copper-Associated Signal Transduction Systems with Their Environment in Marine Bacteria.Microorganisms · 2023Review
- A Copper-Responsive Two-Component System Governs Lipoprotein Remodeling in Listeria monocytogenes.Journal of bacteriology · 2023Article
- Iron-tracking strategies: Chaperones capture iron in the cytosolic labile iron pool.Frontiers in molecular biosciences · 2023Review
- Unique underlying principles shaping copper homeostasis networks.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2022Review
- Regulatory cross-talk supports resistance to Zn intoxication in Streptococcus.PLoS pathogens · 2022Article
- Article
- Bacterial Transcriptional Regulators: A Road Map for Functional, Structural, and Biophysical Characterization.International journal of molecular sciences · 2022Review
- Molecular Evolution of Transition Metal Bioavailability at the Host-Pathogen Interface.Trends in microbiology · 2021Review
- A protease-mediated mechanism regulates the cytochromeProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Enhanced copper-resistance gene repertoire in Alteromonas macleodii strains isolated from copper-treated marine coatings.PloS one · 2021Article
- Structural basis for persulfide-sensing specificity in a transcriptional regulator.Nature chemical biology · 2021Article
- Article
- Electronucleation mechanism of copper in wastewater by controlled electrodeposition analysis.RSC advances · 2020Article
- Multi-metal nutrient restriction and crosstalk in metallostasis systems in microbial pathogens.Current opinion in microbiology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Hendrik GlauningerDepartment of Chemistry , Indiana University , Bloomington , IN 47405-7102 , USA . Email: giedroc@indiana.edu ; Email: dacapdev@iu.edu ; Tel: +1-812-856-3178 ; Tel: +1-812-856-6398.
Yifan ZhangDepartment of Chemistry , Indiana University , Bloomington , IN 47405-7102 , USA . Email: giedroc@indiana.edu ; Email: dacapdev@iu.edu ; Tel: +1-812-856-3178 ; Tel: +1-812-856-6398.
Khadine A HigginsDepartment of Chemistry , Indiana University , Bloomington , IN 47405-7102 , USA . Email: giedroc@indiana.edu ; Email: dacapdev@iu.edu ; Tel: +1-812-856-3178 ; Tel: +1-812-856-6398.
Alexander D JacobsDepartment of Chemistry , Indiana University , Bloomington , IN 47405-7102 , USA . Email: giedroc@indiana.edu ; Email: dacapdev@iu.edu ; Tel: +1-812-856-3178 ; Tel: +1-812-856-6398.
Julia E MartinDepartment of Chemistry , Indiana University , Bloomington , IN 47405-7102 , USA . Email: giedroc@indiana.edu ; Email: dacapdev@iu.edu ; Tel: +1-812-856-3178 ; Tel: +1-812-856-6398.
Yue FuDepartment of Chemistry , Indiana University , Bloomington , IN 47405-7102 , USA . Email: giedroc@indiana.edu ; Email: dacapdev@iu.edu ; Tel: +1-812-856-3178 ; Tel: +1-812-856-6398.
H Jerome Coyne RdDepartment of Chemistry , Indiana University , Bloomington , IN 47405-7102 , USA . Email: giedroc@indiana.edu ; Email: dacapdev@iu.edu ; Tel: +1-812-856-3178 ; Tel: +1-812-856-6398.
Kevin E BruceDepartment of Biology , Indiana University , Bloomington , IN 47405 , USA.
Michael J MaroneyDepartment of Chemistry , University of Massachusetts , Amherst , MA 01003 , USA.
David E ClemmerDepartment of Chemistry , Indiana University , Bloomington , IN 47405-7102 , USA . Email: giedroc@indiana.edu ; Email: dacapdev@iu.edu ; Tel: +1-812-856-3178 ; Tel: +1-812-856-6398.
Daiana A CapdevilaDepartment of Chemistry , Indiana University , Bloomington , IN 47405-7102 , USA . Email: giedroc@indiana.edu ; Email: dacapdev@iu.edu ; Tel: +1-812-856-3178 ; Tel: +1-812-856-6398.
David P GiedrocDepartment of Chemistry , Indiana University , Bloomington , IN 47405-7102 , USA . Email: giedroc@indiana.edu ; Email: dacapdev@iu.edu ; Tel: +1-812-856-3178 ; Tel: +1-812-856-6398.ORCID 0000-0002-2342-1620
Bloomington Health Foundation · USUniversity of Massachusetts Amherst · US
Funding
Transition Metal Homeostasis and Reactive Sulfur Species in Bacterial PathogensR35GM118157 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI DAVID P. GIEDROC · 2016 to 2026
$5.9MZINC COORDINATION AND REGULATION OF ZINC METALLOPROTEINSR01GM042569 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI GIEDROC, DAVID P. · 1996 to 2015
$4.9MStructural Parameters Involved in Metal RecognitionR01GM069696 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI MARONEY, MICHAEL J · 2004 to 2017
$3.3MNIGMS NIH HHS R01 GM042569NIGMS NIH HHS R01 GM069696NIGMS NIH HHS R35 GM118157
Abstract
Resistance to copper (Cu) toxicity in the respiratory pathogen
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.